ROCIT Example Data and Cell Atlas Reference

This release contains two files for use with the ROCIT toolkit for read-origin classification in tumors using CpG methylation data obtained from long-read whole-genome sequencing.

cell_map_reference_atlas.parquet — Precomputed reference CpG methylation atlas derived from normal human cell types. This file is required by ROCIT for tumor-origin classification. Derived from the normal human cell-type methylation data released by Loyfer et al.

Loyfer, N., et al. (2023). A DNA methylation atlas of normal human cell types. Nature.

HG008_example_data.tar — Example input files for the ROCIT preprocessing pipeline, derived from HG008 tumor and matched normal HiFi reads sequenced with Pacbio Revio. Includes a subsampled BAM file (with index), copy number, haplotype, variant, and cluster annotation tables.

McDaniel, J.H., Patel, V., Olson, N.D. et al. (2025). Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair. Scientific Data.