Adenocarcinoma Admixed Neuroendocrine Carcinoma: A rare Case Report of 39 Years Old Women

Introduction: Neuroendocrine carcinoma coexisted with adenocarcinoma in cervix is very rare. This disease have a very poor prognosis and so far no standard treatment has been obtained.

Case Illustration: A 39-years-old woman seeks medical attention with chief complaint of bleeding outside of menstruation. Ultrasound: EL (+) enlarged portio with a mass of 3.8 cm × 2.7 cm. Microscopic biopsy conclusion was obtained a mixture of adenocarcinoma and neuroendocrine cervical carcinoma, moderate-bad differentiation. Several Immunohistochemical staining of the biopsy tissue was done to detect neuroendocrine and adenocarcinoma. Also P63 was performed to dismissed squamous cell carcinoma.

Discussion: In biopsy tissue, P63 immunohistochemical staining was performed to detect squamous cell carcinoma with negative results. Furthermore chromogranin, synaptophycin, CD 56, NSE, and P40 immunohistochemical staining were performed to detect neuroendocrine with positive results and so did CK 19, CEA, and CK 7 staining to detect positive adenocarcinomas.

Conclusion: This rare case had a positive immunohistochemical staining of both neuroendocrine carcinoma and adenocarcinoma cervix.