Targeted Acoustic Ablation of Arterial Calcification via Biomimetic Nanocarriers: A Structural and Kinetic Protocol

Current interventions for advanced atherosclerosis rely on brute-force mechanical disrup-
tion of calcified plaques, presenting significant risks of macroscopic emboli and downstream
ischemia. We propose a non-surgical clearance modality utilizing targeted, biomimetic
acoustic nanocarriers to induce localized brittle failure of arterial calcification. By exploit-
ing the profound acoustic impedance mismatch between rigid hydroxyapatite lattices and
the highly compliant extracellular matrix, an attenuated, high-frequency acoustic standing
wave (1 MHz – 4 MHz) can selectively pulverize the calcified lattice layer-by-layer. Delivered
via lipid-polymeric micro-emitters engineered with strict spatial, electrostatic, and temporal
constraints, this method offers a mathematically self-regulating pathway for restoring arte-
rial elasticity without generating macroscopic debris or risking systemic bioaccumulation.