Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse model

Included are the code, markdown files, and example data supporting the RNAseq and proteomic analysis in the manuscript Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse model in Nature Communications on April 23, 2026 at the DOI: https://doi.org/10.1038/s41467-026-71919-6.

Included are Linux and R code.

An earlier version of the manuscript is also available on BioRxiv at https://www.biorxiv.org/content/10.1101/2024.06.19.599752v1.

See README file for further description of the code, files, and data included in this upload.

Example data also include RNAseq and proteomics data from previous the manuscripts below:

Boisvert, M. M., Erikson, G. A., Shokhirev, M. N. & Allen, N. J. The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain. Cell Rep. 22, 269–285 (2018).

Caldwell, A. L. M. et al. Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders. Nat. Neurosci. 25, 1163–1178 (2022).

Darnell, J. C. et al. FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism. Cell 146, 247–261 (2011).

Divolis, G. et al. Activation of both transforming growth factor-β and bone morphogenetic protein signalling pathways upon traumatic brain injury restrains pro-inflammatory and boosts tissue reparatory responses of reactive astrocytes and microglia. Brain Commun. 1, fcz028 (2019).

Zhang, Y. et al. An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex. J. Neurosci. 34, 11929–11947 (2014).