Published February 27, 2026 | Version v1
Journal article Open

FORMULATION AND EVALUATION OF ANTIDIABETIC HERBAL CHOCOLATE USING AEGLE MARMELOS LEAVES

Authors/Creators

  • 1. Associate Professor, Department of Pharmaceutical Analysis, Dhanalakshmi Srinivasan College of Pharmacy, Tamilnadu.
  • 2. Associate Professor, Department of Pharmaceutical Chemistry, Dhanalakshmi Srinivasan College of Pharmacy, Tamil Nadu.
  • 3. Student, Deportment of Pharmaceutical Chemisty, JKK Nataraja College of Pharmacy, Komarapalayam, Tamil Nadu.

Description

The study was concluded the active constituents present in Aegle marmelos leaves extract exhibit the superior inhibition against diabetic activity. The chocolate formulation results shown in the specific limits for the respective evaluation, parameters of color, texture and chemical composition variation melting point, physical stability. The alkaloids present in the leaves are well extracted through 95% ethanol. During separation, it was observed under UV light 366nm the alkaloids are separated successfully by thin layer chromatography technique.

Files

6 WJPSR 2081.pdf

Files (1.2 MB)

Name Size Download all
md5:df12a8cebbac9898c6684d3042f4bb2c
1.2 MB Preview Download

Additional details

References

  • 1. Beverley B, Eschwège E. The diagnosis and classification of diabetes and impaired glucose tolerance. In: Textbook of Diabetes 1 Ed: John C Pickup and Gareth Williams Third edition, Chapter, 2003.
  • 2. Lindberg G, Lindblad U, Melander A. Sulfonylureas for treating type 2 diabetes mellitus. Cochrane Database Systemic Reviews, 2004; 3.
  • 3. Bearse MA Jr, Han T, Schneck ME, et al. Local multifocal oscillatory potential abnormalities in diabetes and early diabetic retinopathy. Invest Ophthal Vis Sci, 2004.
  • 4. Hove MN, Kristensen JK, Lauritzen T, Bek T. The prevalence of retinopathy in an unselected population of type 2 diabetes patients from Arhus County, Denmark. Acta Ophthalmol Scand, 2004.
  • 5. Seki M, Tanaka T, Nawa H, et al. Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factors for dopaminergic amacrine cells. Diabetes, 2004.
  • 5. Seki M, Tanaka T, Nawa H, et al. Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factors for dopaminergic amacrine cells. Diabetes, 2004.
  • 7. Huang C, Kim Y, Caramori ML, et al. Cellular basis of diabetic nephropathy: II. The transforming growth factor-beta system and diabetic nephropathy lesions in type 1 diabetes. Diabetes, 2002.
  • 8. Shukla N, Angelini GD, Jeremy JY, et al. Homocysteine as a risk factor for nephropathy and retinopathy in type 2 diabetes. Diabetologia, 2003.
  • 9. Svensson M, Eriksson JW, Dahlquist G. Early glycemic control, age at onset, and development of microvascular complications in childhood-onset type 1 diabetes: a population-based study in northern Sweden. Diabetes Care, 2004.
  • 10. Mohn A, Strang S, Wernicke-Panteau J, et al. Nocturnal glucose control and free insulin levels in children with type 1 diabetes by use of the long-acting HOE901 as part of a three-injection regimen. Diabetes Care, 2000.
  • 11. Keller K, Whittaker E, Sullivan L, et al. Effect of restricting dietary protein on the progression of renal failure in patients with insulin-dependent diabetes mellitus. N Eng J Med, 1991.
  • 12. Betterle C, Zannette F, Pedini B, et al. Clinical and subclinical organ-specific autoimmune manifestations in type 1 (insulin-dependent) diabetic patients and their first-degree relatives. Diabetologia, 1983.
  • 13. Anderson RA, Cheng N, Bryden NA, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes, 1997.
  • 14. Eriksson J, Saloranta C, Widen E, et al. Non-esterified fatty acids do not contribute to insulin resistance in persons at increased risk of developing type 2 (non insulin- dependent) diabetes mellitus, Diabetologia, 1991.
  • 15. Saely CH, Aczel S, Marte T, et al. Cardiovascular complications in type 2 diabetes mellitus depend on the coronary angiographic state rather than on the diabetes state. Diabetologia, 2004.
  • 16. Kintzios SE. Terrestrial plant-derived anticancer agents and plant species used in anticancer research. Critical reviews in plant sciences, 2006 May 1.
  • 17. Neeraj VB, Johar V. Bael (Aegle marmelos) extraordinary species of India: a review. Int. J. Curr. Microbiol. Appl. Sci, 2017.
  • 18. Sharma N, Dubey W. History and taxonomy of Aegle marmelos: a review. International Journal of Pure and Applied Bioscience, 2013.
  • 19. Om P. Food and Drinks in Ancient India, from Earliest Times to c. 1200 ad.1961.
  • 20. Agarwal VS. Rural economics of medicinal plants: vegetation in the forests. Drug plants of India, 1997.
  • 21. Panditrao SS. Development of RP-HPLC method for standardization of Aegle marmelos (L.). World Journal of Advanced Research and Reviews, 2020.
  • 22. Saliya Parveen Gulam Rasool, European journal of pharmaceutical and medical research, 2022 March 20.
  • 23. Kriti sharma, Nutritional and phytochemical evaluation of fruit pulp powder Aegle marmelos, 2017.
  • 24. Sabira mustaq, International journal of research granthaalayah, 2017 August.
  • 25. Biswas K, Chatopadhyay I, Banerjee R.K., and Bandhopadhyay U., "Biological Activities and Medicinal Properties of neem (Azadirachta indica), Curr Sci, 2002; 82.
  • 26. Gupta A.K., and Tondon N., "Review on Indian medicinal plants", Indian council of medicinal research, New Delhi, 2004; 312.
  • 27. Sundaram, E.N., Raddy, Uma Maheswara P and Singh K.P., "Effect of Alcoholic Extracts of Indian Medicinal Plants on the Altered Enzymatic Activities of Diabetic Rats", 2009.
  • 28. Ghangale G. R., Surve V. S., Anbarasan K. and Gatne M. M., "Evaluation of Aegle marmelos (Bael) for anti-inflammatory activity in rats" The Journal of Bombay Veterinary College, 2008; 16(1).
  • 29. Arul, V., Miyazaki, S and Dhananjayan R., "Studies on the anti inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr.", Journal of Ethnopharmacology, 2005.
  • 30. Shankarnanth V., Balakrishnan N., Suresh D., Sureshpandian G., Edwin E. and Sheeja E., "Analgesic activity of methanol; extract of Aegle marmelos leaves", Fitoterapia, 78(3).
  • 31. Citarasu, T., Rajajeyasekar, R., Venkatmalingam K., Dhandapani, P. S and Peter Marian M., "Effect of wood apple Aegle marmelos, Correa ( Diacotyledons, Sapindales, Rutaceae) Extract as an antibacterial agent on pathogens infecting prawn ( Penaeus indicus) larviculture", Indian Journal of Marine Sciences, 2003.
  • 32. Kaur, S., Kaur, P., Walia, A. and Kumar, S., "Antigenotoxic Activity of PolyphenolicnRich Extracts from Aegle marmelos (L.) Correa in Human Blood, 2009.