Effect of Zingiber Officinale Ethanol Extract on Reproductive Hormones of Male Albino Wistar Rats Induced with Inflammation

Abstract: Reproductive function is known to be disrupted by inflammation, and Zingiber
officinale, has long been used to treat inflammatory diseases. In this work, male albino Wistar
rats with albumin-induced inflammation were used to assess the modulatory effects of Zingiber
officinale ethanol extract on reproductive hormones, such as testosterone, follicle-stimulating
hormone (FSH), and luteinizing hormone (LH). A control group, an inflammation-induced
group, and groups treated with different dosages of Zingiber officinale ethanol extract
comprised the five (5) groups of thirty (30) male albino Wistar rats. Albumin was used to cause
inflammation, and the extract was taken orally for three weeks. Standard laboratory methods,
such as enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA), were used
to evaluate hormone levels. The results showed that Zingiber officinale ethanol extract
significantly modulated reproductive hormone levels in the treated groups compared to the
control groups. Specifically, testosterone levels increased (14.39 ± 0.0003), while FSH and LH
levels showed dose-dependent responses. The findings suggest that Zingiber officinale ethanol
extract may have a regulatory effect on reproductive hormone production in male albino Wistar
rats with albumin-induced inflammation, potentially due to its anti-inflammatory and
antioxidant properties. These results have potential implications for the treatment of
reproductive disorders associated with inflammation and warrant further investigation into the
mechanisms underlying the modulatory effects of Zingiber officinale on reproductive
hormones.