Transcriptomic clock models and rodent gene expression meta-dataset

Tyshkovskiy, Alexander; Glubokov, Dmitrii; Molière, Adrian; Gladyshev, Vadim

doi:10.5281/zenodo.18763485

Published February 25, 2026 | Version v1

Model Open

Transcriptomic clock models and rodent gene expression meta-dataset

1. Harvard Medical School
2. Mass General Brigham
3. ETH Zurich
4. Brigham and Women's Hospital

Contributors

1. Brigham and Women's Hospital
2. Harvard Medical School
3. Mass General Brigham

Transcriptomic clock models and rodent gene expression meta-dataset

This Zenodo record contains processed expression data and transcriptomic clock models in .pkl format generated in the manuscript "Universal Transcriptomic Hallmarks of Mammalian Aging and Mortality". Scripts for preprocessing and model application are available in GitHub repository (https://github.com/Gladyshev-Lab/tAge). Raw RNA-seq data are available at GEO under accession numbers GSE292843, GSE292884, and GSE293503, and are linked under the SuperSeries GSE292885. These models are provided for research use as described in the repository license.

Citation

Tyshkovskiy et al. (2026) Universal Transcriptomic Hallmarks of Mammalian Ageing and Mortality. Nature.

License

These transcriptomic clock models and associated tAge R package are distributed under the MGB Open Access License 1.0. These materials may be used for non-commercial academic purposes, subject to the license terms. Commercial uses require a separate commercial license or agreement with Mass General Brigham.

https://github.com/Gladyshev-Lab/tAge/blob/main/LICENSE

For questions about commercial use, please contact MGB Innovation / Business Development & Licensing:

Files

Expression_data_absolute_rodents_Scaled.csv

Files (63.8 GB)

Name	Size	Download all
BR_Chronoage_Mouse_Multitissue_scaleddiff.pkl md5:aa9f753dc279eac9688f08ef0de1e569	2.4 GB	Download
BR_Chronoage_Mouse_Multitissue_yugenediff.pkl md5:c77c24d194a983cece0a7e1ce3cbcebd	2.4 GB	Download
BR_Chronoage_Multispecies_Multitissue_scaleddiff.pkl md5:efa60dab8b6160bfd39381be73acee9f	880.6 MB	Download
BR_Chronoage_Multispecies_Multitissue_yugenediff.pkl md5:c33d7b7ec750249f55967079b27bc37d	880.6 MB	Download
BR_Chronoage_Rodents_Brain_WT_scaleddiff.pkl md5:3f6921476fb19693ac84146635373817	2.2 GB	Download
BR_Chronoage_Rodents_Brain_WT_yugenediff.pkl md5:68e03da91cf58a53c202ad1b223baaab	2.2 GB	Download
BR_Chronoage_Rodents_Kidney_WT_scaleddiff.pkl md5:065b5f041f73e26d7f9719dd24e569dc	2.0 GB	Download
BR_Chronoage_Rodents_Kidney_WT_yugenediff.pkl md5:6f87c9be1ba1cb7d3efb45f9f8efbf34	2.0 GB	Download
BR_Chronoage_Rodents_Liver_scaleddiff.pkl md5:8c9bf298ab0783145f8721bcb4fc32b2	2.1 GB	Download
BR_Chronoage_Rodents_Liver_yugenediff.pkl md5:a9f74d3b86c0b5e29b0d56caab184fec	2.1 GB	Download
BR_Chronoage_Rodents_Multitissue_scaleddiff.pkl md5:eddcba9e9a2cbff21f01ce23d27cd73e	2.2 GB	Download
BR_Chronoage_Rodents_Multitissue_yugenediff.pkl md5:509e45c1d11e7278066ae1e7ffa4b3fc	2.2 GB	Download
BR_Chronoage_Rodents_Skeletal muscle_WT_yugenediff.pkl md5:c6ebdc57c4ef19fbce4a21da6678147d	1.9 GB	Download
BR_Chronoage_Rodents_Skeletal_muscle_WT_scaleddiff.pkl md5:aaf40e3c69042ff8f0c0cad8c432d25c	1.9 GB	Download
BR_Mortality_Mouse_Multitissue_scaleddiff.pkl md5:8ff83db036636b11a8da86b5adaecabc	2.4 GB	Download
BR_Mortality_Mouse_Multitissue_yugenediff.pkl md5:daea37146186fda8b5a7f258ac3b8b9b	2.4 GB	Download
BR_Mortality_Multispecies_Multitissue_scaleddiff.pkl md5:20fedb08b78828b8a355c5a53c9da369	880.6 MB	Download
BR_Mortality_Multispecies_Multitissue_yugenediff.pkl md5:8a123360449cd022d695c783a4b13d6c	880.6 MB	Download
BR_Mortality_Rodents_Liver_scaleddiff.pkl md5:6e378ec38438dc4919125c4dcb5b18c3	2.1 GB	Download
BR_Mortality_Rodents_Liver_yugenediff.pkl md5:de581da49e81703429d07109293fdb39	2.2 GB	Download
BR_Mortality_Rodents_Multitissue_scaleddiff.pkl md5:da7dc56fada1ddb89bb4c6a0b947faca	2.2 GB	Download
BR_Mortality_Rodents_Multitissue_yugenediff.pkl md5:4b316c2ba5397a3ba3db57c159cf68aa	2.3 GB	Download
BR_NormalizedAge_Mouse_Multitissue_scaleddiff.pkl md5:8d1d0ac05cd33945666b7b5149341703	2.4 GB	Download
BR_NormalizedAge_Mouse_Multitissue_yugenediff.pkl md5:61c07c0d58f0e05de4bd639e8ced88bb	2.4 GB	Download
BR_NormalizedAge_Multispecies_Multitissue_scaleddiff.pkl md5:e7b8d25fb30d82aec0a9e0c071ad9a83	880.6 MB	Download
BR_NormalizedAge_Multispecies_Multitissue_yugenediff.pkl md5:a09fbc41ccc94202ed280a194e3447cf	880.6 MB	Download
BR_NormalizedAge_Rodents_Liver_scaleddiff.pkl md5:fb1da22da9a43058d49c655c53a3e02d	2.1 GB	Download
BR_NormalizedAge_Rodents_Liver_yugenediff.pkl md5:53f38dbc98ffa9df5ce532a5e42ea0a2	2.2 GB	Download
BR_NormalizedAge_Rodents_Multitissue_scaleddiff.pkl md5:6f9063381b97f56d1932aeecb7f91ed1	2.2 GB	Download
BR_NormalizedAge_Rodents_Multitissue_yugenediff.pkl md5:67bdc7efb474f2b69e7d9bcc17338530	2.3 GB	Download
Data_annotation_absolute_rodents.xlsx md5:4153c6e6c755f61d3dbd3721554f34c7	393.4 kB	Download
Data_annotation_relative_rodents.xlsx md5:bb56d389a63c76f02c4e1b98319d6bd8	496.2 kB	Download
EN_Chronoage_Mouse_Multitissue_scaleddiff.pkl md5:c31d3b5ea8af7aa0891aee12d95109b5	956.0 kB	Download
EN_Chronoage_Mouse_Multitissue_yugenediff.pkl md5:7dff7ed53329448476836fa052ed6097	960.8 kB	Download
EN_Chronoage_Multispecies_Multitissue_scaleddiff.pkl md5:7dc8a470f5db20a75d7052829efbd37a	584.9 kB	Download
EN_Chronoage_Multispecies_Multitissue_yugenediff.pkl md5:ad893ce7c008094b9f36450257d1934a	584.9 kB	Download
EN_Chronoage_Rodents_Brain_scaleddiff.pkl md5:035013a679acd5ddb4ecb5f092626b6d	921.1 kB	Download
EN_Chronoage_Rodents_Brain_yugenediff.pkl md5:4de57fb362eb885013bb0edd0150a3d7	925.9 kB	Download
EN_Chronoage_Rodents_Kidney_scaleddiff.pkl md5:c58a1430f36c738cc3d72825f28d44ec	871.7 kB	Download
EN_Chronoage_Rodents_Kidney_yugenediff.pkl md5:5a465266c64f29187fff656231d5a8d6	874.7 kB	Download
EN_Chronoage_Rodents_Liver_scaleddiff.pkl md5:a73012b22b5f4bc9881edd1ac2b0cb72	909.9 kB	Download
EN_Chronoage_Rodents_Liver_yugenediff.pkl md5:1967d3ea992f697ae7c1761ac9bf1aea	912.4 kB	Download
EN_Chronoage_Rodents_Multitissue_scaleddiff.pkl md5:19fee9e782b4eda36ab13a459fcdb3db	921.3 kB	Download
EN_Chronoage_Rodents_Multitissue_yugenediff.pkl md5:2e19c9ef45b45ffdebd0b2882722041a	924.7 kB	Download
EN_Chronoage_Rodents_Skeletal_muscle_scaleddiff.pkl md5:5640befd2990e1601e86b0ccfcbaf771	861.7 kB	Download
EN_Chronoage_Rodents_Skeletal_muscle_yugenediff.pkl md5:30f9e2cc01a982bbf2e7deaee4aab62f	864.1 kB	Download
EN_Mortality_Mouse_Multitissue_scaleddiff.pkl md5:43ee221e8cbe8577107f1a74230891e0	964.5 kB	Download
EN_Mortality_Mouse_Multitissue_yugenediff.pkl md5:a96f0068691f853a89e9c28935d49561	970.1 kB	Download
EN_Mortality_Multispecies_Multitissue_scaleddiff.pkl md5:87307d7f5572d9932382912d3fd9571c	584.9 kB	Download
EN_Mortality_Multispecies_Multitissue_yugenediff.pkl md5:bd371c5a7c6706c363dcac9662ceab00	584.9 kB	Download
EN_Mortality_Rodents_Liver_scaleddiff.pkl md5:cd76d203c42f88a7580707c36a7e4a0b	913.8 kB	Download
EN_Mortality_Rodents_Liver_yugenediff.pkl md5:d4d0f33b64f23b734c3e95d06e78eba3	918.5 kB	Download
EN_Mortality_Rodents_Multitissue_scaleddiff.pkl md5:26cc9e089e45bf978205738e56f190fb	934.8 kB	Download
EN_Mortality_Rodents_Multitissue_yugenediff.pkl md5:27e6fcd83926eb3fc3680fa0ab23c5ff	938.5 kB	Download
EN_NormalizedAge_Mouse_Multitissue_scaleddiff.pkl md5:fc3ddb5a235db2d280f1fd37284f9f73	964.5 kB	Download
EN_NormalizedAge_Mouse_Multitissue_yugenediff.pkl md5:c3ef18b0b8a8ae5609f9b41cd87234af	970.1 kB	Download
EN_NormalizedAge_Multispecies_Multitissue_scaleddiff.pkl md5:a009e1cc7049c7cfc7efd41e1c348476	584.9 kB	Download
EN_NormalizedAge_Multispecies_Multitissue_yugenediff.pkl md5:634b7ef57c1ce535cce1172023f444b3	584.9 kB	Download
EN_NormalizedAge_Rodents_Liver_scaleddiff.pkl md5:791f866582741402cabb6eed4c0bde30	913.8 kB	Download
EN_NormalizedAge_Rodents_Liver_yugenediff.pkl md5:8dabb0f4f2354d9e0eaff2b01e3113db	918.5 kB	Download
EN_NormalizedAge_Rodents_Multitissue_scaleddiff.pkl md5:bbf2b0f8feecaafb29456e3403616144	934.8 kB	Download
EN_NormalizedAge_Rodents_Multitissue_yugenediff.pkl md5:b37545ab983594d4eae123ce7947c880	938.5 kB	Download
Expression_data_absolute_rodents.rds md5:9d4d8627f548a73e8cb851ea2d2f1d13	615.6 MB	Download
Expression_data_absolute_rodents_Scaled.csv md5:3b182622809b1361a6266f119102d017	1.1 GB	Preview Download
Expression_data_absolute_rodents_YuGene.csv md5:c822d9bcf3cb05f516ce8408fe5a08f3	1.1 GB	Preview Download
Expression_data_relative_rodents.rds md5:16af0a906aa243a7066894242fb6f3c9	891.8 MB	Download
Expression_data_relative_rodents_Scaled.csv md5:c283869cf69e35afa200c6a6fc281519	721.7 MB	Preview Download
Expression_data_relative_rodents_YuGene.csv md5:26a44ce691c5781bcbd4f3c2423b198b	1.2 GB	Preview Download

Additional details

Is supplement to: Publication: 10.1038/s41586-026-10542-3 (DOI)

Repository URL: https://github.com/Gladyshev-Lab/tAge
Programming language: Python , R

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Zenodo

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Technical metadata

Created: March 1, 2026
Modified: May 27, 2026

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Transcriptomic clock models and rodent gene expression meta-dataset

Citation

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Expression_data_absolute_rodents_Scaled.csv

Files (63.8 GB)

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Transcriptomic clock models and rodent gene expression meta-dataset

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Contributors

Contact person:

Data manager:

Supervisor:

Description

Transcriptomic clock models and rodent gene expression meta-dataset

Citation

License

Files

Expression_data_absolute_rodents_Scaled.csv

Files (63.8 GB)

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