TwoSampleMR R package

Published June 10, 2026 | Version v0.7.8

Software Open

Fixed a copy-paste bug in ldsc_rg() which passed d1$l2 instead of d2$l2 as the weight vector to the trait-2 ldsc_h2_internal() call
Fixed extract_split() chunking which gave nsplit = 0 for SNP lists smaller than half the splitsize; now uses ceiling() with contiguous chunk ids
Fixed the penalised mode in mr_mode() for vector-valued phi: each SNP is now penalised against the weighted-mode estimate for the same phi rather than recycling the mode vector across SNPs (results unchanged for the default scalar phi = 1)
Fixed row order restoration in add_metadata() to use dat[order(dat[[order_col]]), ]
Qualified a bare aes() call as ggplot2::aes() in test_r_from_pn()
Used isTRUE(all.equal()) instead of all.equal() == TRUE inside ifelse() for null-line detection in the forest plot functions, which could otherwise return a multi-element vector
Simplified the group Index assignment in forest_plot_1_to_many() using Letters[match()], which is also robust to non-contiguous group rows
Collapsed a duplicated || condition in extract_outcome_data_internal()
Removed dead TAUsq accumulation in PM() in rucker.R
Fixed an error message typo in combine_data() and switched its sapply() to vapply()
Replaced superseded tidyr::gather() with tidyr::pivot_longer() in test_r_from_pn() and dropped a redundant requireNamespace("tidyr") guard
Lint package with Jarl

Notes

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MRCIEU/TwoSampleMR-v0.7.8.zip md5:7d5176501e7e22c53f00adac39e5d130	6.1 MB	Preview Download

Is supplement to: Software: https://github.com/MRCIEU/TwoSampleMR/tree/v0.7.8 (URL)