Published February 24, 2026
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MECHANISTIC STUDY OF MELATONIN: A SYSTEMATIC REVIEW
Authors/Creators
- 1. 1. Department of Physiology, Faculty of Basic Medical Sciences,College of Health Sciences, Usmanu Dan fodiyo University, Sokoto, Nigeria.
Description
Background: Melatonin, a neurohormone synthesized primarily in the pineal gland, plays a central role in regulating circadian rhythms and sleep-wake cycles.
Purpose: Beyond its chronobiotic functions,melatonin exhibits potent a ntioxidant,anti inflammatory, immunomodulatory,and oncostatic proper ties.This review explores the multifaceted molecular and cellular mecha nisms of melatonin across physiological and pathological conditions.
Methods: A systematic review following PRISMA guidelines was conducted using databases including PubMed, Scopus, Web of Science, and Google Scholar. Studies from 1990 to 2024 focusing on mechanisti c insights were included.
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