Published February 23, 2026 | Version v1
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Towards improved anticancer properties of the G-quadruplex-forming T40231 aptamer through increased flexibility of nucleoside residues

Authors/Creators

  • 1. Institute of Bioorganic Chemistry PAS
  • 2. Institute of Bioorganic Chemistry
  • 3. Institute of Bioorganic Chemistry, PAS

Description

Raw data and data accompanying publication:
Kotkowiak W., Bartyś N., Pasternak A. (2025) Towards improved anticancer properties of the G-quadruplexforming T40231 aptamer through increased flexibility of nucleoside residues. Sci. Rep. 15: 25159. 
Authors: Weronika Kotkowiak (1), Natalia Bartyś (1), Anna Pasternak (1)
Affiliation:

(1) Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
* Corresponding author: e-mail: apa@ibch.poznan.pl

This study was supported by National Science Centre, Poland grants: 020/37/B/NZ7/02008 to A.P., 2021/41/B/
NZ7/03910 to W.K., 2024/08/X/ST4/00521 to N.B.

Contents:
(1)Serum stability data
(2)Thermal stability data
(3)Native gel high-resolution image file
(4)Circular dichroism data
(5)qPCR data
(6)Antiproliferative assay data

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Additional details

Funding

National Science Centre
Foldback triplex-forming oligonucleotides as novel tools for G-quadruplex unfolding and selective inhibition of c-Myc oncogene transcription 2020/37/B/NZ7/02008
National Science Centre
Thrombin binding aptamer with expanded chemical diversity as potential anticoagulant and anticancer agent 2021/41/B/NZ7/03910
National Science Centre
Thermodynamic identification and characterization of G-quadruplex structures in RON protooncogene pre-mRNA 2024/08/X/ST4/00521