Published February 1, 2026
| Version v2
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A guide to selecting high-performing antibodies for TREM2 (Q5TCX1) for use in western blot, immunoprecipitation and immunofluorescence
Authors/Creators
-
1.
Montreal Neurological Institute and Hospital
- 2. The Montreal Neurological Institute
Contributors
Researcher:
Description
Here we have characterized fourteen TREM2 commercial antibodies for western blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. This project was supported by Structural Genomics Consortium, a registered charity (no. 1097737). The Structural Genomics Consortium receives funding from Bayer AG, Boehringer Ingelheim, Bristol-Myers Squibb, Genentech, Genome Canada through Ontario Genomics Institute (grant no. OGI196), the EU and EFPIA through the Innovative Medicines Initiative 2 Joint Undertaking (EUbOPEN grant no. 875510), Janssen, Merck KGaA (also known as EMD in Canada and the United States), Pfizer and Takeda.
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TREM2_YCharOS report-v6.pdf
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