Published February 20, 2026 | Version 2
Dataset Open

RovHer: heritability-optimized scores for the functional prioritization of rare missense variants

Authors/Creators

  • 1. ROR icon McMaster University
  • 2. ROR icon Population Health Research Institute

Description

A heritability-optimized scoring method using multivariate adaptive regression splines that incorporates 75 variant- and gene-level features. RovHer leverages exome-wide association statistics to train models estimating the probability of RV functional impact. This is version 2 of the scores.

Files

All_RovHer_Scores_final_80M.txt

Files (3.2 GB)

Name Size
md5:ec8e1994aff2f7f32b127d8985c99992
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Additional details

Dates

Updated
2026-02-20
Final version of the RovHer score

Software

Repository URL
https://github.com/Keonapang/RovHer
Programming language
R
Development Status
Active