Published February 19, 2026 | Version v2
Preprint Open

Stakeholder-centered Design of Explainable AI for MRI analysis in Multiple Sclerosis: Generative insights toward clinical integration

Authors/Creators

  • 1. EPFL+ECAL Lab, École polytechnique fédérale de Lausanne, Lausanne, Switzerland
  • 2. Faculty of Biology and Medicine, University of Lausanne (UNIL), Lausanne, Switzerland
  • 3. Radiology Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  • 4. Institute of Informatics, University of Applied Sciences Western Switzerland (HES-SO Valais) Sierre, Switzerland
  • 5. CIBM Center for Biomedical Imaging, Lausanne, Switzerland
  • 6. Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland
  • 7. Department of Neurology, University Hospital Basel, Basel, Switzerland
  • 8. Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland
  • 9. Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland
  • 10. Multiple Sclerosis Centre, Departments of Neurology, Clinical Research and Biomedicine, University Hospital and University Basel, Switzerland
  • 11. Department of Health Sciences, University of Genova, 16132 Genova, Italy
  • 12. Department of Medical Radiology, Service of Diagnostic and Interventional Radiology, Neuroradiology Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
  • 13. Department of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel and University of Basel, Basel, Switzerland
  • 14. Nuclear Medicine and Molecular Imaging Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  • 15. Politecnico di Milano, Department of Design, Milan, Italy
  • 16. ARTORG Center for Biomedical Engineering Research, University of Bern, Bern,Switzerland
  • 17. Department of Radiation Oncology, Inselspital, Bern University Hospital andUniversity of Bern, Bern, Switzerland
  • 18. Faculté de droit, des sciences criminelles et d'administration publique, Lab' Santé et droit, Université de Lausanne, Lausanne, Switzerland
  • 19. Faculté de biologie et de médecine, Institut des Humanités en Médecine, Université de Lausanne, Lausanne, Switzerland
  • 20. The Sense Innovation and Research Center, Sion, and Lausanne, Switzerland
  • 21. Medical faculty, University of Geneva, Geneva, Switzerland
  • 22. University of Basel
  • 23. University Hospital of Lausanne

Description

This is a preprint of an article submitted for consideration in PLOS Digital Health

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Motta_et_al_2025_XAI_MS_Radiology_Preprint.pdf

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Additional details

Dates

Submitted
2026-02-19