Published January 31, 2026 | Version v1
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A Review of Dengue Virus Transmission, Replication, Structural and Non-Structural Proteins

Authors/Creators

  • 1. Department of Zoology, University of Lucknow, Lucknow (UP), India.

Description

Dengue fever is an arboviral disease transmitted by mosquitos. There are currently no viable vaccinations for this major public health issue in tropical and subtropical regions.

Every year, around 400 million people become infected with the Dengue virus, with a fatality rate of about 40% of patients with severe dengue infection. The Dengue virus belongs to Flaviviridae family. Research on this Dengue virus infection cycle identified possible host targets for transmission and replication. In this review, we discuss the structural and non-structural proteins of Dengue virus and their activities.

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References

  • 1. Pinheiro. FP, Corber.SJ (1997). "Global situation of dengue and dengue haemorrhagic fever, and its emergence in the Americas,"12 BioMed Research International World Health Statistics Quarterly, vol. 50, no. 3-4, pp. 161–169. 2. WHO (2021). Dengue and Severe Dengue; WHO: Geneva, Switzerland. 3. Mustafa, M.; Rasotgi, V.; Jain, S.; Gupta, V (2015). Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in dengue control. Medical Journal of Armed Forces India. 71, 67–70. 4. Xu, M.; Züst, R.; Toh, Y.X.; Pfaff, J.M.; Kahle, K.M.; Davidson, E.; Doranz, B.J.; Velumani, S.; Tukijan, F.; Wang, C.-I (2016). Protective Capacity of the Human Anamnestic Antibody Response during Acute Dengue Virus Infection. Journal of Virology. 90, 11122–11131. 5. Pierson, T.C.; Kielian, M (2013). Flaviviruses: Breaking the entering. Current Opinion in Virolology. 3, 3–12. 6. Rawlinson, S.M.; Pryor, M.J.; Wright, P.J.; Jans, D.A (2006). Dengue virus RNA polymerase NS5: A potential therapeutic target? Curr. Drug Targets. 7, 1623–1638. 7. Barnard, T.R.; Abram, Q.H.; Lin, Q.F.; Wang, A.B.; Sagan, S.M (2021). Molecular Determinants of Flavivirus Virion Assembly. Trends in Biochemical Sciences. 46, 378–390. 8. Nasar, S.; Rashid, N.; Iftikhar, S (2020). Dengue proteins with their role in pathogenesis, and strategies for developing an effective anti-dengue treatment: A review. Journal of Medical Virology. 92, 941–955. 9. Vossmann, S.; Wieseler, J.; Kerber, R.; Kummerer, B.M (2015). A basic cluster in the N terminus of yellow fever virus NS2A contributes to infectious particle production. Journal of Virology. 89, 4951–4965. 10. Leung, J.Y.; Pijlman, G.P.; Kondratieva, N.; Hyde, J.; Mackenzie, J.M.; Khromykh, A.A (2008). Role of nonstructural protein NS2A in flavivirus assembly. Journal of Virology. 82, 4731–4741. 11. O'Connor, O.; Ou, T.P.; Aubry, F.; Dabo, S.; Russet, S.; Girault, D.; In, S.; Minier, M.; Hoem, T.; Boyer (2021). Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings. Emerg. Microbes and Infection. 10, 1346–1357. 12. Urcuqui-Inchima, S.; Patiño, C.; Torres, S.; Haenni, A.-L.; Díaz, F.J (2010). Recent Developments in Understanding Dengue Virus Replication. Advance in Virus Research. 77, 1–39. 13. Uno, N. and Ross, T.M. (2018). Dengue virus and the host innate immune response. Emerging Microbes Infections., 7: 167. 14. Byk, L.A. and Gamarnik, A.V. (2016). Properties and functions of the dengue virus capsid protein. Annual Revolution of Virology. 3: 263–281. 15. Perera, R. and Kuhn, R.J. (2008). Structural proteomics of dengue virus. Current Opinion of Microbiology. 11: 369–377. 16. Nasar, S., Rashid, N. and Iftikhar, S. (2020). Dengue proteins with their role in pathogenesis, and strategies for developing an effective anti-dengue treatment: A review. Journal of Medical Virolology, 92: 941–955. 17. Keelapang, P., Sriburi, R., Supasa, S., Panyadee, N., Songjaeng, A., Jairungsri, A. (2004). Alterations of pr-M cleavage and virus export in pr-M junction chimeric dengue viruses. Journal of Virology, 78: 2367–2381. 18. Behnam, M.A.M., Nitsche, C., Boldescu, V. and Klein, C.D. (2016). The medicinal chemistry of dengue virus. Journal of Medicinal Chemistry., 59: 5622–5649. 19. Alen, M.M.F., Schols, D. (2012). Dengue virus entry as a target for antiviral therapy. Journal of Tropical Medicine. 2012: 628475. 20. Naresh, P., Selvaraj, A., Shyam Sundar, P., Murugesan, S., Sathianarayanan, S., Namboori P.K. and Jubie, S. (2020). Targeting a conserved pocket (n-octyl-β-Dglucoside) on the dengue virus envelope protein by small bioactive molecule inhibitors. Journal of Biomolecular Structure and Dynamics., 40: 4866–4878. 21. Dwivedi, V.D., Tripathi, I.P. and Tripathi, R.C. (2017). Genomics, proteomics and evolution of dengue virus. Briefing in Functional Genomics., 16: 217–227. 22. Modhiran, N., Watterson, D., Muller, D.A., Panetta, A.K., Sester, D.P. and Liu, L. (2015). Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicene., 7: 304ra142. 23. Shrivastava, G., García-Cordero, J., León-Juárez, M., Oza, G., Tapia-Ramírez, J. and Villegas-Sepulveda, N. (2017). NS2A comprises a putative viroporin of Dengue virus 2. Virulence. 8: 1450–1456. 24. Xie, X., Zou, J., Zhang, X., Zhou, Y. and Routh, A.L. et al. (2019). Dengue NS2A Protein Orchestrates Virus Assembly. Cell Host Microbe. 26: 606–622.e8. 25. Gopala Reddy, S.B., Chin, W.X. and Shivananju, N.S. (2018). Dengue virus NS2 and NS4: Minor proteins, mammoth roles. Biochemical Pharmacology. 154: 54–63. 26. Dighe, S.N.; Ekwudu, O.; Dua, K.; Chellappan, D.K.; Katavic, P.L.; Collet, T.A. (2019). Recent update on anti-dengue drug discovery. European. Journal of Medicinal Chemistry. 176: 431–455. 27. Phoo, W.W., El Sahili, A., Zhang, Z.Z., Chen, M.W., Liew, C.W. and Lescar, J. (2020). Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3. Antiviral Research. 182: 104900. 28. Xie, X., Zou, J., Wang, Q.Y. and Shi, P.Y. (2015). Targeting dengue virus NS4B protein for drug discovery. Antiviral Research. 118: 39–45. 29. Miller, S., Sparacio, S. and Bartenschlager, R. (2006). Subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4B. Journal of Biological Chemistry., 281: 8854–8863. 30. Anil K, Hridayesh A, Prveen V, Sanjay S, Vishan K, Surbhi M, Manish M, Prem S, Anand P, Sonal S and Keshav S. (2023). A Review of Dengue Virus Genome, Structural and Non-Structural Proteins, And Life Cycle. Journal of Science Innovations and Nature of Earth. 3(2):6-16.