LMX1b is a component homeobox in the TE specification program.

We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of Lmx1b as a lineage commitment factor in embryonic stem cells of the human embryo. We present evidence in the same report an Lmx1b-associated non-coding RNA also with functions in trophectoderm fate choice decisions.