Published February 12, 2026 | Version v1
Publication Open

Quantifying the spatiotemporal dynamics of the first two epidemic waves of SARS-CoV-2 infections in the United States

  • 1. Yale School of Public Health, Yale University
  • 2. ROR icon Yale University
  • 3. ROR icon Harvard University
  • 4. Stanford University
  • 5. Yale School of Public Health

Description

SARS-CoV-2 infection rates displayed strikingly organized patterns of temporal and spatial spread as new variants were introduced and subsequently transmitted within the United States. While these spatiotemporal "waves" of infection have been described previously, attempts to quantify the speed and extent of these waves have been limited. Here, we estimate and compare the wavefront speed and spatial expansion of the first two major infection waves in the United States, illustrating these dynamics through detailed visualizations. Our findings reveal that the origins of these waves coincide with large gatherings and the relaxation of masking mandates. Notably, we found that the second wave spread more rapidly than the first, possibly driven by multiple introduction events. These analyses highlight regional heterogeneity in epidemic dynamics and underscore the importance of localized public health measures in mitigating ongoing outbreaks.

Files

waves-waves-manuscript.zip

Files (552.5 MB)

Name Size Download all
md5:ee5c04fa28cfd5826c60d797225eb8ee
552.5 MB Preview Download

Additional details

Software

Repository URL
https://github.com/covidestim/waves
Programming language
R