Published February 12, 2026
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Wnt6, Bmp7, and Fgf19 define commitment to the TE in human pluripotent stem cells.
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We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of Wnt6, Bmp7 and Fgf19 as lineage commitment factors or lineage commitment cooperating factors in embryonic stem cells of the human embryo.
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Wnt6 functions in lineage commitment in the human embryo. (2).pdf
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