Published February 8, 2026 | Version v2
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Functionalized sepiolite incorporated chitosan/poly(ethylene glycol) hydrogels for wound dressing and sustained silver sulfadiazine release

Authors/Creators

  • 1. ROR icon Capital University of Science and Technology
  • 2. ROR icon University of the Punjab
  • 3. Services hospital Lahore
  • 4. ROR icon Pir Mehr Ali Shah Arid Agriculture University
  • 5. ROR icon University of Veterinary and Animal Sciences
  • 6. ROR icon Allama Iqbal Open University

Description

Silver sulfadiazine (AgSD) belongs to the class of sulfonamides, a broad spectrum antibiotic. However, topically AgSD has limited bioavailability, less solubility and poor penetration. Consequently, we have prepared functionalized sepiolite (F-SEP) incorporating chitosan (CS) and poly(ethylene glycol) (PEG) hydrogels for improved AgSD delivery and wound dressing applications. In 30 hours, 81.27% of the drug was released which is superior from numerous studies and depicted best fit for Korsmyer-Peppas model (R2-0.978). The biodegradable and pH responsive CS/PEG/F-SEP hydrogel platform could be a valuable choice for sustained delivery of AgSD and therapeutic payloads for development of efficient dressings for healing wounds.

Methods

Firstly, sepilite clay was functionalized using   3-aminopropyl(triethoxy)silane (APTS)  cross-linker. 

Subsequently, chitosan, PEG, functionalized sepilite (F-SEP) were used to prepare hydrogels using solution casting technique. 

The data was collected by the synthesis, characterization and analysis of hydrogels.

 

Series information

Five hydrogels were prepared coded below:

SAR(cont) = Chitosan (0.5g)+ PEG (0.5g) + F-SEP (0.0 mg)

SAR-5 = Chitosan (0.5g)+ PEG (0.5g) + F-SEP (5.0 mg)

SAR-10 = Chitosan (0.5g)+ PEG (0.5g) + F-SEP (10.0 mg)

SAR-15 = Chitosan (0.5g)+ PEG (0.5g) + F-SEP (15.0 mg)

SAR-20 = Chitosan (0.5g)+ PEG (0.5g) + F-SEP (20.0 mg)

DSAR-15 = Chitosan (0.5g)+ PEG (0.5g) + F-SEP (15.0 mg) + AgSD (100.0 mg)

Notes

Further, the data was acquired from IR, TGA, swelling analysis (in distilled water, buffer/non-buffer and ionic solutions), cell viability assay,shore A hardness, encapsulation efficacy, AgSD release and release kinetics.

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Software

Development Status
Active