THERMODYNAMIC PROPERTIES OF DERIVATIVES OF 2-METHYL-5-PHENYL-1R-1HPYRROLE-3-CARBOXYLIC ACIDS IN THE CONDENSED STATE

According to the Paal–Knorr reaction, 1-cyclohexyl-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid and 2-methyl-5-phenyl-1-(4-tolyl)-1H-pyrrole-3-carboxylic acid were synthesized. The main stages of the synthesis were described, and the yields of the target products were determined. The structures of the synthesized compounds were confirmed by nuclear magnetic resonance spectroscopy, and the corresponding NMR spectra are reported.

The potential biological activity of the compounds was evaluated using the PLATO r36 web application. The changes in the internal energy of combustion, as well as the enthalpies of combustion and formation of the synthesized compounds in the condensed state, were experimentally determined using precision calorimetric equipment. Based on the experimental data obtained, the thermodynamic parameters were recalculated to the standard temperature of 298.15 K.