New Mathematics Based on Ethics with Logic
Published May 8, 2026 | Version v4
Preprint Open

Mathematical expression of the logic structure projection theorem under the influence of nonlinear perturbation variable field and Derivation of a Conjecture on the Biological Co-evolutionary Equilibrium from a Formalization Framework --Logical reasoning based on interdisciplinary biomathematics

Authors/Creators

  • 1. Independent researcher

Description

 

Abstract

I have devised new formulas and created novel mathematical concepts and symbols solely through logic and insight. I have updated the concept of “Evolution” in biology, updated the Mathematical Logic with in Virus Transmission Models in Biology, I discussed the concepts of “speed” and “time” in biology. 

  Based on this discussion, I proposed a systematic evolutionary logic conjecture, and a certain branch of this conjecture, namely [Conjecture on the Evolutionary Theory of Selection-Determined Orientation] , I proposed a Conjecture on Co-evolutionary Pathways, by considering the relationship between local perturbations and systemic change, this groundwork paves the way for the theory I will subsequently propose.

  I have written three sets of formulae. The first is a Mathematical expression of the logic structure projection theorem under the influence of nonlinear perturbation variable Sphere—a novel mathematical concept of my own creation. For this formula, I introduced three new notations: [projection], [tend to], and [Path-Feedback-Expression]. The second set is aMathematical Expression of Multidimensional Infection Pathways Projection. The third set comprises the derivation of the formula for the [Biological Co-evolutionary EquilibriumFormalization system] .

 

Key words : conservation;biological co-evolutionary;Evolution; Biomathematics ; Math

 

------

This record permanently preserves the original Chinese manuscript of this research and its accompanying English translation. It is created to:
1. Establish the intellectual provenance of the work, acknowledging that its core ideas were conceived and articulated in Chinese.
2. Provide direct access to the [source text] for scholars interested in precise terminology, theoretical nuance, or translation studies.

Relationship to Other Preprints
An English version of this work has been submitted to SSRN for broader academic exposure. This Zenodo archive remains the authoritative source for the original Chinese text.

Citation Suggestion
When analyzing conceptual origins, linguistic details, or translation fidelity, cite this Zenodo record (specifying the Chinese PDF as needed).

-----

Important Note on Translation & Terminology (Updated: 2026-02-11)


A preliminary full calibration of the English terminology and expressions was completed on February 12. Further revisions will follow as needed.

-----

Important Note  (Updated: 2026-04-28)

I have updated the [Manifesto by Ethical of mine].

------

Important Note (Updated: 2026-05-08)
The original term “filed” has been changed to “sphere.”
Font formatting has been adjusted.

Files

Logical reasoning based on interdisciplinary biomathematics_KuiyuanBu卜奎元_Chinese.pdf

Files (4.0 MB)

Additional details

Identifiers

Other
https://ssrn.com/abstract=6139912

Dates

Created
2025-12-11
Date of final manuscript completion [2025-12-11]

References

  • Euler, L. (1797). Introductio in analysin infinitorum (Vol. 2). Apud Bernuset, Delamolliere, Falque & soc..
  • Jedlicka, F. (1836). De morbis contagiosis. Vetterl.
  • Snow, J. (1855). On the Mode of Communication of Cholera. John Churchill.
  • Koch, R. (1882). Die aetiologie der tuberkulose.
  • Pasteur, L., Chamberland, C., & Roux, E. (1885). Méthode pour prévenir la rage après morsure. Comptes Rendus de l'Académie des Sciences, 101, 765–774.
  • Stratman-Thomas, W. K. (1930). GIROLAMO FRACASTORO (1478-1553)—AND SYPHILIS. California and western medicine, 33(4), 739.
  • Bahmanyar, M., Fayaz, A., Nour-Salehi, S., Mohammadi, M., & Koprowski, H. (1976). Successful protection of humans exposed to rabies infection. Postexposure treatment with the new human diploid cell rabies vaccine and antirabies serum. JAMA, 236(24), 2751–2754.
  • World Health Organization (1976). Weekly Epidemiological Record, 1976, vol. 51, 42 [full issue]. Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 51(42), 325 - 332. https://iris.who.int/handle/10665/221076
  • Emond, R. T. D., Evans, B., Bowen, E. T. W., & Lloyd, G. (1977). A case of Ebola virus infection. British Medical Journal, 2(6086), 541–544.https://doi.org/10.1136/bmj.2.6086.541
  • Johnson, K. M., Lange, J. V., Webb, P. A., & Murphy, F. A. (1977)."Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire."The Lancet, 309(8011), 569–571.DOI: 10.1016/S0140-6736(77)92000- 1
  • World Health Organization. (1978). Ebola virus haemorrhagic fever: Proceedings of an international colloquium on Ebola virus infection and other haemorrhagic fevers held in Antwerp, Belgium, 6–8 December 1977.Geneva: World Health Organization.
  • Lycke, E. R. I. K., & Tsiang, H. E. N. R. I. (1987). Rabies virus infection of cultured rat sensory neurons. Journal of virology, 61(9), 2733-2741.
  • Fauci, A. S. (1988). The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science, 239(4840), 617-622.
  • Jahrling, P. B., Geisbert, T. W., Dalgard, D. W., Johnson, E. D., Ksiazek, T. G., Hall, W. C., & Peters, C. J. (1990). Preliminary report: Isolation of Ebola virus from monkeys imported to USA. The Lancet, 335(8688), 502- 505. https://doi.org/10.1016/0140-6736(90)90737-P
  • Hook III, E. W., & Marra, C. M. (1992). Acquired syphilis in adults. New England Journal of Medicine, 326(16), 1060-1069.
  • Fine, P. E. (1993). Herd immunity: history, theory, practice. Epidemiologic reviews, 15(2), 265-302.
  • Tsiang, H. (1993). Pathophysiology of rabies virus infection of the nervous system. Advances in virus research, 42, 375-412.
  • Morse, S. S. (1995). Factors in the emergence of infectious diseases. Emerging infectious diseases, 1(1), 7.
  • Le Guenno, B., Formenty, P., Wyers, M., Gounon, P., Walker, F., & Boesch, C. (1995). Isolation and partial characterisation of a new strain of Ebola virus. The Lancet, 345(8961), 1271–1274. https://doi.org/10.1016/S0140- 6736(95)90925-7
  • Zhu, H., Cong, J. P., Mamtora, G., Gingeras, T., & Shenk, T. (1998). Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proceedings of the National Academy of Sciences, 95(24), 14470-14475.
  • Mocroft, A., Vella, S., Benfield, T. L., Chiesi, A., Miller, V., Gargalianos, P. E. A., ... & Lundgren, J. D. (1998). Changing patterns of mortality across Europe in patients infected with HIV-1. The Lancet, 352(9142), 1725-1730.
  • Formenty, P., Hatz, C., Le Guenno, B., Stoll, A., Rogenmoser, P., & Widmer, A. (1999). Human infection due to Ebola virus, subtype Côte d'Ivoire: Clinical and biologic presentation. The Journal of Infectious Diseases, 179(Suppl 1), S48–S53. https://doi.org/10.1086/514285
  • Peters, C. J., & LeDuc, J. W. (1999). An introduction to Ebola: The virus and the disease. Journal of Infectious Diseases, 179(Suppl. 1), ix–xvi. https://doi.org/10.1086/514322
  • Hemachudha, T., Laothamatas, J., & Rupprecht, C. E. (2002). Human rabies: a disease of complex neuropathogenetic mechanisms and diagnostic challenges. The Lancet Neurology, 1(2), 101-109.
  • Towner, J. S., Sealy, T. K., Khristova, M. L., Albariño, C. G., Conlan, S., Reeder, S. A., Quan, P.-L., Lipkin, W. I., Downing, R., Tappero, J. W., Okware, S., Lutwama, J., Bakamutumaho, B., Kayiwa, J., Comer, J. A., Rollin, P. E., Logical reasoning based on Interdisciplinary Biomathematics | Kuiyuan Bu | CC BY-NC-ND 4.0| 2025-12-11 32 Ksiazek, T. G., & Nichol, S. T. (2008). Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS Pathogens, 4(11), e1000212. https://doi.org/10.1371/journal.ppat.1000212
  • Mocroft, A., Ledergerber, B., Katlama, C., Kirk, O., Reiss, D. P., Monforte, A. D. A., ... & Lundgren, J. D. (2003). Decline in the AIDS and death rates in the EuroSIDA study: an observational study. The Lancet, 362(9377), 22-29.
  • Hirokawa, N., Noda, Y., Tanaka, Y., & Niwa, S. (2009). Kinesin superfamily motor proteins and intracellular transport. Nature reviews Molecular cell biology, 10(10), 682-696.
  • Verhey, K. J., & Hammond, J. W. (2009). Traffic control: regulation of kinesin motors. Nature reviews Molecular cell biology, 10(11), 765-777.
  • Davies, J., & Davies, D. (2010). Origins and evolution of antibiotic resistance. Microbiology and molecular biology reviews, 74(3), 417-433.
  • Tang, K. W., Alaei-Mahabadi, B., Samuelsson, T., Lindh, M., & Larsson, E. (2013). The landscape of viral expression and host gene fusion and adaptation in human cancer. Nature communications, 4(1), 2513.
  • Van Kerkhove MD, Bento AI, Mills HL, Ferguson NM, Donnelly CA. (2015). A review of epidemiological parameters from Ebola outbreaks to inform early public health decision-making. Sci. Data 2, 150019. (doi:10.1038/sdata.2015.19)
  • Garske, T., Cori, A., Ariyarajah, A., Blake, I. M., Dorigatti, I., Eckmanns, T., ... & Donnelly, C. A. (2017). Heterogeneities in the case fatality ratio in the West African Ebola outbreak 2013–2016. Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1721), 20160308.
  • Goldstein, T., Anthony, S. J., Gbakima, A., Bird, B. H., Bangura, J., Tremeau-Bravard, A., ... & Mazet, J. A. (2018). Discovery of a new ebolavirus (Bombali virus) in molossid bats in Sierra Leone. Nature microbiology, 3(10), 1084.
  • Malvy, D., McElroy, A. K., de Clerck, H., Günther, S., & van Griensven, J. (2019). Ebola virus disease. The Lancet, 393(10174), 936-948.
  • Argyropoulos, K. V., Serrano, A., Hu, J., Black, M., Feng, X., Shen, G., ... & Jour, G. (2020). Association of initial viral load in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients with outcome and symptoms. The American journal of pathology, 190(9), 1881-1887.
  • Lee, S., Kim, T., Lee, E., Lee, C., Kim, H., Rhee, H., ... & Kim, T. H. (2020). Clinical course and molecular viral shedding among asymptomatic and symptomatic patients with SARS-CoV-2 infection in a community treatment center in the Republic of Korea. JAMA internal medicine, 180(11), 1447-1452.
  • Zheng, Y., Xu, H., Yang, M., Zeng, Y., Chen, H., Liu, R., ... & Wang, D. (2020). Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. Journal of Clinical Virology, 127, 104366.
  • Zhao, J., Gao, H. Y., Feng, Z. Y., & Wu, Q. J. (2020). A retrospective analysis of the clinical and epidemiological characteristics of COVID-19 patients in Henan Provincial People's Hospital, Zhengzhou, China. Frontiers in Medicine, 7, 286.
  • Hasanoglu, I., Korukluoglu, G., Asilturk, D., Cosgun, Y., Kalem, A. K., Altas, A. B., ... & Guner, R. (2021). Higher viral loads in asymptomatic COVID-19 patients might be the invisible part of the iceberg. Infection, 49(1), 117-126.
  • Schiffman, Z., Yan, F., He, S., Tierney, K., Zhu, W., Emeterio, K., ... & Qiu, X. (2021). Taï Forest virus does not cause lethal disease in ferrets. Microorganisms, 9(2), 213.
  • Wu, Q., Shi, L., Li, H., Huang, S., Li, H., Li, L., ... & Pei, Z. (2022). Viral RNA Load in Symptomatic and Asymptomatic COVID‐19 Omicron Variant‐Positive Patients. Canadian Respiratory Journal, 2022(1), 5460400.
  • Barragan, N. C., Wickramasekaran, R. N., Sorvillo, F., Smith, L. V., & Kuo, T. (2023). Current trends in syphilis mortality in the United States, 2015–2020. Venereology, 2(2), 59-64.
  • Tao, Y. T., Gao, T. Y., Li, H. Y., Ma, Y. T., Li, H. J., Xian-Yu, C. Y., ... & Zhang, C. (2023). Global, regional, and national trends of syphilis from 1990 to 2019: the 2019 global burden of disease study. BMC Public Health, 23(1), 754. Horita, N., & Fukumoto, T. (2022). Global case fatality rate from COVID‐19 has decreased by 96.8% during 2.5 years of the pandemic. Journal of medical virology, 95(1), e28231.
  • Bu, Kuiyuan. (2025). "From Coercion to Coordination: Game Theory and Institutional Logic in Healthcare Crisis Response, A Multidisciplinary Framework for Policy, Culture and Strategic Management Based on Macro and Micro Perspectives." A Multidisciplinary Framework for Policy, Culture and Strategic Management Based on Macro and Micro Perspectives (March 11, 2025) .