Design And Development of Emulgel Containing Ibuprofen Using Central Composite Design

Ibuprofen is chosen as the drug in the emulgel.  Emulgel accommodates oil soluble drugs and enhances penetration of the drug. Ibuprofen (iso-butyl-phenyl-propionic acid) is a nonsteroidal anti-inflammatory drug (NSAID) that is used for treating pain, fever, and inflammation. Peceol oil is chosen in emulgel . Peceol oil is an oily vehicle used as a solubilizer for lipophilic APIs in oral and topical formulations. Ibuprofen emulgel is formulated by using Peceol Oil, Oleic Acid , Tween 20, Span 20, Liquid Paraffin, Carbopol940. Viscosity and Spreading Coefficient, pH, dilution test, centrifuge test, skin irritation, and analgesic activity are evaluated.   The concentration of Peceol Oil and Oleic Acid is varied and the effect is seen in the parameters like viscosity and spreading coefficient using Design-Expert 13. Optimized Formulation shows good spreading coefficient and Viscosity. Analgesic activity showed similar results like marketed formulation.