Childhood Mixed Connective Tissue Disease: A Literature Review

Mixed Connective Tissue Disease (MCTD) is a rare autoimmune condition characterized by overlapping clinical manifestations of systemic lupus erythematosus, scleroderma, and polymyositis, associated with high titers of anti-U1 RNP antibodies. In children, MCTD presents specific diagnostic and therapeutic challenges due to the variability of clinical manifestations and a distinct immune response compared to adults.