Management of Resistant Hypertension: Recent Major Advances

Resistant Hypertension (RH) is characterized by persistently elevated blood pressure despite the use of at least three antihypertensive drug classes, including a diuretic, in adequate doses. This condition presents a clinical challenge due to the significantly increased cardiovascular risk and associated morbidity and mortality. In recent years, RH management has evolved considerably, driven by advancements in pharmacological interventions, non-pharmacological techniques and patient stratification based on genetic factors and biomarkers. Effective treatment requires a multidisciplinary approach, ranging from lifestyle modifications and medication adherence monitoring to the utilization of technologies such as renal sympathetic denervation and baroreflex devices.