Published January 31, 2026
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Familial Metachronous Wilms' Tumour in a Sibling with Previous Bilateral Synchronous Wilms' Tumour: A Rare Familial Cluster
Authors/Creators
- 1. Department of Pediatrics and Pediatric Surgery, Postgraduate Institute of Child Health & Research and KT Children Govt. University Teaching Hospital, Rajkot 360001, Gujarat, India
- 2. Formerly Head, Department of Surgery at Tata Memorial Hospital, Mumbai, India
- 3. J. Watumull Global Hospital & Research Centre, Delwara Road, Mount Abu, Rajasthan 307501, India Affiliated to Medical Faculty of God Fatherly Spiritual University, Mount Abu, Rajasthan, India
Description
Abstract
Wilms Tumour (WT) is the most common renal malignancy of childhood, typically occurring sporadically. Familial WT accounts for fewer than 2% of cases and often involves germline predisposition syndromes. Metachronous WT in siblings - particularly when one sibling previously presented with bilateral synchronous disease - is exceptionally rare. We report a case of a child presenting with unilateral WT whose older sibling had been treated several years earlier for bilateral synchronous WT. This case highlights the importance of familial risk assessment, genetic counselling, structured surveillance, and early detection strategies in families with suspected hereditary WT predisposition.
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Additional details
Identifiers
Dates
- Submitted
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2026-01-04
- Accepted
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2026-01-29
- Available
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2026-01-31