Published February 4, 2026 | Version v2.00
Other Open

TP53: CanVIG-UK Gene-Specific Guidance

Authors/Creators

  • 1. Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK
  • 2. North East and Yorkshire Genomic Laboratory Hub, Sheffield Children's NHS Foundation Trust, Sheffield, UK
  • 3. Manchester Centre for Genomic Medicine and NW Laboratory Genetics Hub, Manchester University Hospitals NHS Foundation Trust, Manchester, UK
  • 4. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
  • 5. The Leeds Genetics Laboratory, NEY Genomic Laboratory Hub, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  • 6. Central and South Genomics Laboratory Hub, Wessex Genomics Laboratory Service, University Hospital Southampton NHS Foundation Trust, Salisbury, UK
  • 7. Genomics and Molecular Medicine Service, Nottingham University Hospitals NHS Trust, Nottingham, UK
  • 8. St George's University Hospitals NHS Foundation Trust, Tooting, London, UK
  • 9. Wales Genomic Health Centre, Cardiff and Vale University Health Board, Cardiff, UK
  • 10. Laboratory Genetics, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK
  • 11. South East Scotland Clinical Genetics, Western General Hospital, Edinburgh, UK
  • 12. Department of Clinical Genetics, CHI at Crumlin, Dublin, Ireland
  • 13. West Midlands Genomics Laboratory, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK
  • 14. North Bristol NHS Trust, Southmead Hospital, Bristol, UK
  • 15. Belfast Health and Social Care Trust, Royal Victoria Hospital, Belfast, UK
  • 16. The Royal Marsden NHS Foundation Trust, Fulham Road, London
  • 17. Peninsula Regional Genetics Service, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK
  • 18. Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom

Description

CanVIG-UK review of TP53 04/02/2026: Consensus to use relevant recommendations from the ClinGen TP53 Expert Panel, Variant Interpretation Guidelines for TP53 Version 2.4.0 (available at: https://cspec.genome.network/cspec/ui/svi/affiliation/50013). Additional points of specification are given below where applicable.

Additional note: Please defer to the TP53 VCEP guidelines for evidence combination rules - If any codes should not be used together or if there is any danger of double counting, this is addressed in the caveat language for the rule.

Files

CanVIG_TP53_gene_specific_v2.0_04022026.pdf

Files (714.7 kB)

Name Size Download all
md5:1c6125eefac7b37a25c83b42238062e3
714.7 kB Preview Download

Additional details

Identifiers

URL
https://www.cangene-canvaruk.org/gene-specific-recommendations