USP deubiquitinase function is likely required in the human embryo during differentiation to the trophectoderm.

We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here identification of deubiquitinases from the USP family as lineage commitment cooperating molecules in embryonic stem cells of the human embryo.