An Association Study of STAT6 Gene Polymorphism with Asthma

The human signal transducer and activator of transcription 6 (STAT6) gene represents one of the most promising candidate genes for asthma and other inflammatory diseases on the chromosomal region 12q13–q24. Therefore, Bronchial asthma is a common disease with multiple determinants that include genetic variation. Signal transducer and activator of transcription 6 (STAT6) is a central molecule in the signal transduction pathway used by interleukin-4 (IL-4) in immunoglobulin E (IgE) isotype switching. Signal transducer and activator of transcription 6 (STAT6) is a key transcription factor involved in both interleukin-4 (IL-4) and IL-13-mediated biological responses, such as allergies. Recently, we reported that the polymorphism of the STAT6 gene exon 1 was associated with allergic diseases, while another group studied the G2964A variant of the STAT6 gene’s association with atopic asthma. Genotype frequency between Asthma patient and healthy control groups were slightly different and but not significantly associated with Asthma (χ2=2.025,P=0.3633).  Thus allele frequency (χ2=0.8091, P=0.3684) and carriage rate (χ2=0.4590, P=0.4981) were also not significantly different between both case and control groups.An odds ratio of 0.7860 in Asthma group respectively for ‘CC’ genotype indicated a no role in protective effect of this wild type genotype.