Published February 3, 2026
| Version v1
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CLINICAL AND PATHOPHYSIOLOGICAL ASPECTS OF VIRAL HEPATITI
Authors/Creators
- 1. Independent researcher of medical centre in Bangladesh
Description
Viral hepatitis represents a major global health burden, affecting millions of people worldwide and causing significant morbidity and mortality. The disease is primarily caused by hepatotropic viruses (hepatitis A, B, C, D, and E), each with distinct transmission routes, clinical manifestations, and long-term outcomes. Chronic viral hepatitis, particularly types B and C, is strongly associated with cirrhosis and hepatocellular carcinoma, making it a critical focus for prevention and treatment. This article reviews the pathophysiological mechanisms, clinical features, and pharmacological management of viral hepatitis, highlighting current challenges and advances in antiviral therapy.
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Additional details
References
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- Terrault, N. A., Lok, A. S., McMahon, B. J., Chang, K. M., Hwang, J. P., et al. (2018). Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 guidance. Hepatology, 67(4), 1560–1599.
- Pawlotsky, J. M. (2016). Hepatitis C virus resistance to direct-acting antiviral drugs in interferon-free regimens. Gastroenterology, 151(1), 70–86.
- Ringehan, M., McKeating, J. A., & Protzer, U. (2017). Viral hepatitis and liver cancer. Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1732), 20160274.
- Polaris Observatory Collaborators. (2022). Global prevalence and genotype distribution of hepatitis C virus infection. The Lancet Gastroenterology & Hepatology, 7(8), 724–735.