Published February 19, 2026
| Version v2
Preprint
Open
Stakeholder-centered Design of Explainable AI for MRI analysis in Multiple Sclerosis: Generative insights toward clinical integration
Authors/Creators
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Motta, Margherita1
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Zhan, Wen1
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Molchanova, Nataliia2, 3, 4, 5
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Spagnolo, Federico6, 7, 8
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Baez Lugo, Sebastian1
- Clara, Evans1
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M. Gordaliza, Pedro5, 3, 2
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Cagol, Alessandro9, 10, 11, 8
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Dunet, Vincent12
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Pistocchi, Silvia12
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Mutke, Matthias Anthony13
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Borràs Ferrís, Lluís4, 14
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Gobbo, Beatrice15
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Reyes, Mauricio16, 17
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Ruberte, Esther9, 8
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Erard, Frederic18, 19
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Henchoz, Nicolas1
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Müller, Henning4, 20, 21
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Granziera, Cristina22, 23, 9, 10, 8
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Depeursinge, Adrien4, 14
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Bach Cuadra, Meritxell5, 3, 2
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Ribes Lemay, Delphine1
- 1. EPFL+ECAL Lab, École polytechnique fédérale de Lausanne, Lausanne, Switzerland
- 2. Faculty of Biology and Medicine, University of Lausanne (UNIL), Lausanne, Switzerland
- 3. Radiology Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland
- 4. Institute of Informatics, University of Applied Sciences Western Switzerland (HES-SO Valais) Sierre, Switzerland
- 5. CIBM Center for Biomedical Imaging, Lausanne, Switzerland
- 6. Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland
- 7. Department of Neurology, University Hospital Basel, Basel, Switzerland
- 8. Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland
- 9. Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland
- 10. Multiple Sclerosis Centre, Departments of Neurology, Clinical Research and Biomedicine, University Hospital and University Basel, Switzerland
- 11. Department of Health Sciences, University of Genova, 16132 Genova, Italy
- 12. Department of Medical Radiology, Service of Diagnostic and Interventional Radiology, Neuroradiology Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- 13. Department of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel and University of Basel, Basel, Switzerland
- 14. Nuclear Medicine and Molecular Imaging Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland
- 15. Politecnico di Milano, Department of Design, Milan, Italy
- 16. ARTORG Center for Biomedical Engineering Research, University of Bern, Bern,Switzerland
- 17. Department of Radiation Oncology, Inselspital, Bern University Hospital andUniversity of Bern, Bern, Switzerland
- 18. Faculté de droit, des sciences criminelles et d'administration publique, Lab' Santé et droit, Université de Lausanne, Lausanne, Switzerland
- 19. Faculté de biologie et de médecine, Institut des Humanités en Médecine, Université de Lausanne, Lausanne, Switzerland
- 20. The Sense Innovation and Research Center, Sion, and Lausanne, Switzerland
- 21. Medical faculty, University of Geneva, Geneva, Switzerland
- 22. University of Basel
- 23. University Hospital of Lausanne
Description
This is a preprint of an article submitted for consideration in PLOS Digital Health
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Motta_et_al_2025_XAI_MS_Radiology_Preprint.pdf
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Additional details
Dates
- Submitted
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2026-02-19