In silico medicine and digital twins (virtual human twins) through the foundational paradigm of in silico oncology: Historical landmarks and current evolutionary status - A Lecture by G. Stamatakos, the Father of In Silico Medicine

This document contains the slides of the global lecture of Research Professor Georgios S. Stamatakos, Father of In Silico Medicine, delivered as a webinar of the Avicenna Alliance - Association for Predictive Medicine, upon invitation on 26 August 2025.

The link to the slides in the Avicenna Alliance Repository is: https://www.avicenna-alliance.com/webinars/61-in-silico-medicine-and-digital-twins-through-the-foundational-paradigm-of-in-silico-oncology-hist.html

Abstract:

A brief yet comprehensive overview of the background history and the formal emergence of in silico medicine as a distinct discipline through its foundational paradigm of in silico radiation oncology in 2002 is presented. To this end, in addition to pertinent peer reviewed scientific articles and other official publications, Google®’s generative AI platform "GEMINI® - Deep Research" has been recruited and its generated reports have been independently validated. The Clinical Oncosimulator, proved to be the first digital twin (virtual human twin) in oncology and beyond - presented in 2007 - is also delineated. Key evolutionary landmarks of in silico oncology and in silico medicine are listed. Oncosimulators for glioblastoma multiforme, paediatric nephroblastoma, lung cancer, breast cancer, cervix cancer, prostate cancer and acute lymphoblastic leukemia, along with their clinical validation and translational statuses are outlined. The current evolutionary status of in silico oncology, including cancer digital (virtual) twins, in conjunction with expected future accomplishments, is sketched.

Relevant Open Access References and Reseources

[1] The video of the Avicenna Alliance - Association for Predictive Medicine webinar lecture of G. Stamatakos (2025) is openly accessible at  https://www.youtube.com/watch?v=ibPPCy-Z3yo&t=5s 

[2] Stamatakos, G. (2026). In Silico Radiation Oncology by Stamatakos et al in Proceedings of the IEEE 2002 – The foundational paper of in silico medicine as a discipline – Open Access Accepted Manuscript.  https://doi.org/10.5281/zenodo.18317235

[3] Stamatakos, G. (2026). History of the emergence and formalization of in silico medicine. Zenodo. https://doi.org/10.5281/zenodo.18328392

[4] Stamatakos, G. (2026, May 27). History of science: the birth of the digital twin in oncology and the development of the Oncosimulator. Zenodo.  https://doi.org/10.5281/zenodo.20412798

[5] Stamatakos, G. (2026, May 27). New postgraduate subject on multiscale cancer modeling and in silico medicine (MSCM & ISM) [2014]. Zenodo https://doi.org/10.5281/zenodo.20414026

Upcoming VPH2026 Conference

G. Stamatakos will chair the session "In Silico Oncology" at the conference VPH2026 (Virtual Physiological Human 2026) in Milan, Italy, 1-4 September 2026. More information is available at:  Stamatakos, G. (2026). VPH 2026 - 9th International Conference on the Virtual Physiological Human. Milan 1-4 September 2026 - Track: IN SILICO ONCOLOGY - Chaired by G. Stamatakos, the Father of In Silico Medicine - CALL FOR ABSTRACTS. Zenodo. https://doi.org/10.5281/zenodo.18399005