Spatiotemporal dynamics of Mcl-1 abundance and its influence on apoptosis susceptibility

Published February 4, 2026 | Version v1

Software Open

1. Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
2. Stuttgart Research Center Systems Biology, University of Stuttgart, 70569 Stuttgart, Germany
3. Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland
4. Centre of Systems Medicine, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland
5. GE HealthCare Technology and Innovation Center, Niskayuna, NY 12309, USA.
6. Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE Northern Ireland, UK.

Model code for the manuscript "Spatiotemporal dynamics of Mcl-1 abundance and its influence on apoptosis susceptibility".

Codes developed for the Mcl-1 regulation model and apoptotic tBid threshold model.

python_library_requirements.txt contains python- and library versions that were used ofr the code.

Files

Name	Size	Download all
Cell_Cycle_Model_Analysis.py md5:cf182c824b7ca58c561edbb37faa28ec	25.1 kB	Download
Cell_Cycle_Model_Simulation.py md5:4c6a70e22dfab74b446db72b23066141	72.3 kB	Download
k_off_fitting.py md5:ac63e98ab8599029c82b49c1e68942cd	68.1 kB	Download
MOMP_threshold_model.py md5:c5479ed0f27cd1f0a71dd9cda009bd28	36.9 kB	Download
python_library_requirements.txt md5:0e507640f35588b0c9b4ce3a473b8d35	9.2 kB	Preview Download