Published January 1, 2025
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Nrf2 Overexpression in Spontaneously Hypertensive Rats Enhances Adipose Tissue Metabolism through Redox-Mediated Suppression of Mitochondrial Oxidative Phosphorylation
Authors/Creators
- 1. Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
- 2. Institut klinicke a experimentalni mediciny
Description
The spontaneously hypertensive rat (SHR) is a widely used model of essential hypertension that also exhibits metabolic disturbances under specific conditions. Oxidative stress plays a central role in the pathogenesis of both hypertension and metabolic dysfunction, with the transcription factor Nrf2 regulating key antioxidant defenses. Here, we examined whether Nrf2 overexpression in the SHR improves adipose tissue metabolism. A mouse Nrf2 transgene under a universal promoter was markedly overexpressed in white adipose tissue, leading to increased insulin sensitivity, reduced saturated fatty acids, and higher n-3 polyunsaturated fatty acids in adipose membrane activities, and decreased lipoperoxidation. Transcriptomic analysis revealed downregulation of oxidative phosphorylation genes. redox-sensitive remodeling of adipose tissue metabolism.
Notes
Supported by the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) - Funded by the European Union – Next Generation EU.
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Related works
- Has metadata
- 41406478 (PMID)
- Is part of
- 0862-8408 (ISSN)
- 1802-9973 (ISSN)
- References
- 10.33549/physiolres.935653 (DOI)