When would you order a connective tissue abnormality panel, including COL5A1, COL5A2, and COL3, to diagnose connective tissue diseases?

Connective tissue abnormality panels, including COL5A1, COL5A2, and COL3A1, are generally considered in the diagnostic process when clinical suspicion arises based on symptoms, history, or specific cases such as Ehlers-Danlos syndrome or unexplained events like SCAD. Testing aims to confirm a suspected diagnosis of a hereditary connective tissue disorder.