Integrative Functional Genomics and Fine-Mapping Identify Regulatory Mechanisms of Multivariate Obesity GWAS and Its Cardiometabolic Implications

Here we construct an integrative multivariate obesity GWAS framework (mvObesity) by jointly modeling five obesity-related traits and systematically integrating functional genomic and single-cell datasets. We delineate shared and trait-specific regulatory architectures, identify high-confidence effector genes, and reveal coordinated neuro-metabolic genetic regulation and cell-type-specific mechanisms underlying cardiometabolic risk.