11 01 Base Architecture Hepatocellular Carcinoma NASH

NASH-related HCC represents a unique metabolic malignancy characterized by profound organellar dysfunction, lipotoxic stress, and oxidative imbalance. Unlike viral-associated HCC,
the NASH-HCC ecosystem is fundamentally driven by lipid overload and mitochondrial fragmentation, creating distinct vulnerabilities tha could potentially be exploitable through precision metabolic targeting.
This framework models tumor progression through quantitative , spatial metabolic heterogeneity, and temporal feedback dynamics—all derived from fundamental
biophysical and biochemical principles rather than empirical data fitting.