Fine-mapping results for the EstBB-UKBB NMR metabolic trait meta-analysis

Files contained in this repository:

1. UKBB_EUR_fine_mapping_with_meta_EUR_lead_variants.parquet - main table with all fine mapped credible sets.
2. UKBB_EUR_fine_mapping_missense_snps.tsv.gz - missense variants among the credible set variants (indentified by Ensembl VEP).
3. UKBB_EUR_fine_mapping_splicing_predictions.tsv.gz - SpliceAI and AlphaGenome predictions for all credible set variants.
4. UKBB_EUR_annotated_high_PIP_variants.tsv.gz - filtered list of PIP > 0.8 variants and credible sets to which they belong, annotated with missense and splicing predictions.

Column names of for the fine mapping results (UKBB_EUR_fine_mapping_with_meta_EUR_lead_variants.parquet)

1. molecular_trait_id - name of metabolic trait
2. region - region in which the credible set variants are situated
3. variant - variant in credible set
4. chromosome - chromosome
5. position - position (GRCh38)
6. ref - reference allele
7. alt - alternative allele
8. maf - minor allele frequency in UKBB_EUR cohort
9. cs_id - credible set ID
10. cs_index - credible set index
11. alpha1 - point estimate of causal effect for signal 1
12. alpha2 - point estimate of causal effect for signal 2
13. alpha3 - point estimate of causal effect for signal 3
14. alpha4 - point estimate of causal effect for signal 4
15. alpha5 - point estimate of causal effect for signal 5
16. alpha6 - point estimate of causal effect for signal 6
17. alpha7 - point estimate of causal effect for signal 7
18. alpha8 - point estimate of causal effect for signal 8
19. alpha9 - point estimate of causal effect for signal 9
20. alpha10 - point estimate of causal effect for signal 10
21. pip - posterior inclusion probability
22. z - Z-score