Pemphigus Vulgaris Unveiled: From Nikolsky's Sign to Immunofluorescence
Authors/Creators
- 1. International Journal of Medical Science and Innovative Research (IJMSIR)
Description
Abstract
Oral pemphigus vulgaris (PV) is a rare, chronic, autoimmune, mucocutaneous disorder characterized by the formation of flaccid blisters and painful erosions, predominantly affecting the oral mucosa. This case report describes a 52-year-old female presenting with ulcerations in the buccal mucosa as well as alveolar mucosa, accompanied by a positive Nikolsky’s sign. Diagnostic investigations including cytology, histopathology, and direct immunofluorescence, confirmed the diagnosis of PV, revealing characteristic features such as suprabasilar split, Tzanck cells, and a “fish-net” pattern of IgG deposition. Early diagnosis and initiation of systemic corticosteroids and immunosuppressive therapy are crucial in reducing morbidity and preventing complications. This report, emphasizes the importance of early recognition, particularly by dental professionals, and highlight the advances in treatment strategies including the role of therapeutic agents like rituximab, in improving patient outcomes.
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References
- 1. Janumpally VT, Gantala R, Katne T, Inukonda LM. Pemphigus vulgaris: a case report. SVS Institute of Dental Sciences. 2022 Jul 7. 2. Bystryn JC, Rudolph JL. Pemphigus. Lancet. 2005; 366(9479):61–73. 3. Ahmed AR, Spigelman Z, Cavacini LA, Posner MR. Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin. N Engl J Med. 2006;355(17):1772–1779. 4. Neville BW, Damm DD, Allen CM, Chi AC. Oral & Maxillofacial Pathology. 4th ed. Elsevier; 2016. 5. Robinson ND, Hashimoto T, Amagai M, Chan LS. The new pemphigus variants. J Am Acad Dermatol. 1999;40(5 Pt 1):649–671. 6. Mutasim DF, Adams BB. Immunofluorescence in dermatology. J Am Acad Dermatol. 2001;45(6):803–822. 7. Fitzpatrick TB et al. Fitzpatrick's Dermatology in General Medicine. 8th ed. McGraw-Hill; 2012. 8. Mignogna MD, Fortuna G, Leuci S, et al. Pemphigus vulgaris: overview and current therapy. Oral Dis. 2008;14(6):580–586. 9. Sami N, Bhol KC, Ahmed AR. Diagnostic features of pemphigus vulgaris. Autoimmunity. 2001; 34 (1): 1–17. 10. Amagai M, Klaus-Kovtun V, Stanley JR. Auto antibodies against a novel epithelial cadherin in pemphigus vulgaris. J Clin Invest. 1991;87(3): 755–760. 11. Banerjee I, Bhowmik B, Maji A, Sinha R. Pemphigus vulgaris – a report of three cases and review of literature. J Oral Med Radiol. [Year 2022] 12. Bagchi S, Chatterjee RP, Das SK, Mahmud SA. Dermatologic and oral manifestations of pemphigus vulgaris: a case report with review. Oral Maxillofac Pathol J. 2019; 10.5005/jp-journals-10037-1161.