Spindle Cell Lesions Complex Diagnostic Entites-A Case Series
- 1. International Journal of Dental Science and Innovative Research (IJDSIR)
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Abstract
Spindle cell lesions of the oral cavity are rare, present considerable diagnostic challenges due to overlapping clinical, radiological, and histopathological features. These lesions ranges from benign proliferations to aggressive sarcomas, making accurate diagnosis critical as treatment and prognosis differ significantly. This paper presents a case series of four patients with spindle cell lesions reported to the Department of Oral Pathology. Detailed history, clinical examination, imaging (CBCT, MRI), histopathology, and immunohistochemistry with markers such as Desmin, S-100, Myogenin, and SMA were used for evaluation. All patients were managed surgically with favorable short-term outcomes. These cases highlight the heterogeneity of spindle cell lesions, where morphology provides important clues but immunohistochemistry is essential for distinguishing mimicking entities such as rhabdomyoma, leiomyoma, schwannoma, and sarcomas. Special stains and molecular correlations may provide additional diagnostic support. Management strategies vary from conservative excision in benign cases to aggressive resection with possible adjuvant therapy in malignant cases. In conclusion, spindle cell lesions of the oral cavity are complex diagnostic entities that demand a multimodal approach integrating clinical, radiological, histological, and immunohistochemical findings to ensure early, precise diagnosis and optimal patient outcomes.
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