Isolated Circulation Systems and Cellular Approaches

ABSTRACT

Although perfusion science has historically been synonymous with cardiopulmonary bypass (CPB) applications, today it has transcended this narrow technical framework to become a multidimensional scientific field at the heart of circulation-based treatment approaches. The maintenance of physiological circulation through artificial systems, the preservation of homeostatic balance, and the application of targeted therapies constitute the contemporary application areas of perfusion science. Definitions by international professional and scientific organisations also reveal that clinical perfusion applications have expanded to encompass isolated organ and limb perfusion, cellular and genetic therapy applications, and translational approaches.

Perfusion science is emerging as a new field of research developing in line with isolated circulation systems and cellular approaches. In this context, perfusion science goes beyond being a technical field that provides macroscopic-level circulatory support; it is positioned as an advanced translational science field that enables the application of targeted treatment strategies at the cellular and molecular levels through circulatory systems.

Keywords: Isolated Organ Perfusion, Extremity Perfusion, Cellular Approaches.