Published November 30, 2025
| Version v1
Journal article
Open
Comparative Evaluation of The Effect of Local Delivery of Hyaluronic Acid and iPRF As An Adjunct To Scaling and Root Planing in The Treatment of Generalized Chronic Periodontitis – A Split Mouth Study
- 1. International Journal of Dental Science and Innovative Research (IJDSIR)
Description
Abstract
Background: Periodontitis is an inflammatory condition affecting the tissues that support teeth, brought on by specific micro-organisms. Local drug delivery system into the pocket achieves a greater concentration of drug locally, providing bactericidal action for periopathogens.
Aim of the study: The purpose of the study was to compare and evaluate the effect of local delivery of hyaluronic acid and iPRF as an adjunct to scaling and root planing in the treatment of generalized chronic periodontitis – a split mouth study.
Materials and Method: 24 patients within age group of 30-60 years visiting the OPD at the Department of Periodontology and Oral Implantology, Luxmi Bai Institute of Dental Sciences & Hospital were included in the study. Subjects were divided into two groups, GROUP A (24 patients)- Treated with SRP + 1% hyaluronic acid and Group B (24 patients)- Treated with SRP + iPRF. All the patients were evaluated on the basis of clinical parameters (GI, PI, PPD and CAL) at the baseline, 4th and 6th week interval.
Conclusion: It is concluded that the PD and CAL improved in Group B (SRP+iPRF) as compared to Group A(SRP+1%HA) at the end of the 6th week whereas PI and GI changes were statistically similar in both the groups.
Files
YOGESH.pdf
Files
(1.0 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:6f36bbab76b23eb86046f9c6835f938d
|
1.0 MB | Preview Download |
Additional details
Software
References
- 1. Adriaens PA, De Boever JA, Loesche WJ. Bacterial invasion in root cementum and radicular dentin of periodontally diseased teeth in humans: a reservoir of periodontopathic bacteria. Journal of periodontology. 1988 Apr;59(4):222-30. 2. Agrawal I, Chandran S, Nadig P. Comparative evaluation of the efficacy of platelet-rich fibrin and calcium phosphosilicate putty alone and in combination in the treatment of intrabony defects: A randomized clinical and radiographic study. Contemporary clinical dentistry. 2017 Apr;8(2):205. 3. Arweiler NB, Pietruska M, Pietruski J, Skurska A, Dolińska E, Heumann C, Auschill TM, Sculean A. Six-month results following treatment of aggressive periodontitis with antimicrobial photodynamic therapy or amoxicillin and metronidazole. Clinical oral investigations. 2014 Dec;18:2129-35. 4. Bartold PM, Page RC. Hyaluronic acid synthesized by fibroblasts cultured from normal and chronically inflamed human gingivae. Collagen and Related Research. 1986 Oct 1;6(4):365-78. 5. Bevilacqua L, Eriani J, Serroni I, Liani G, Borelli V, Castronovo G, Di Lenarda R. Effectiveness of adjunctive subgingival administration of amino acids and sodium hyaluronate gel on clinical and immunological parameters in the treatment of chronic periodontitis. Annali di stomatologia. 2012;3(2):76-81. 6. Bogaerde LV. Treatment of infrabony periodontal defects with esterified hyaluronic acid: clinical report of 19 consecutive lesions. Int J Periodontics Restorative Dent. 2009 May;29(3):315-23. 7. Chauhan AS, Bains VK, Gupta V, Singh GP, Patil SS. Comparative analysis of hyaluronan gel and xanthan-based chlorhexidine gel, as adjunct to scaling and root planing with scaling and root planing alone in the treatment of chronic periodontitis: A preliminary study. Contemporary clinical dentistry. 2013 Jan;4(1):54. 8. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):299-303. 9. Eick S, Renatus A, Heinicke M, Pfister W, Stratul SI, Jentsch H. Hyaluronic acid as an adjunct after scaling and root planing: a prospective randomized clinical trial. Journal of periodontology. 2013 Jul;84(7):941-9. 10. Engstrüm PE, Shi XQ, Tronje G, Larsson A, Welander U, Frithiof L, Engstrom GN. The effect of hyaluronan on bone and soft tissue and immune response in wound healing. Journal of periodontology. 2001 Sep;72(9):1192-200. 11. Fawzy El-Sayed KM, Dahaba MA, Aboul-Ela S, Darhous MS. Local application of hyaluronan gel in conjunction with periodontal surgery: A randomized controlled trial. Clinical oral investigations. 2012 Aug;16:1229-36. 12. Gontiya G, Galgali SR. Effect of hyaluronan on periodontitis: A clinical and histological study. Journal of Indian Society of Periodontology. 2012 Apr;16(2):184. 13. Huojel P.P. (2002) Non surgical Periodontal therapy. Periodontology 2000, 28 (1), 59-71. 14. Johannsen A, Tellefsen M, Wikesjö U, Johannsen G. Local delivery of hyaluronan as an adjunct to scaling and root planing in the treatment of chronic periodontitis. Journal of periodontology. 2009 Sep;80(9):1493-7. 15. Killoy WJ. Chemical treatment of periodontitis: local delivery of antimicrobials. International dental journal. 1998 Jun;48(S3):305-15. 16. Mesa FL, Aneiros J, Cabrera A, Bravo M, Caballero T, Revelles F, Del Moral RG, O'Valle F. Antiproliferative effect of topic hyaluronic acid gel. Study in gingival biopsies of patients with periodontal disease. Histology and histopathology. 2002. 17. Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, Choukroun J. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?. Clinical oral investigations. 2017 Nov;21:2619-27. 18. Moseley R, Waddington RJ, Embery G. Hyaluronan and its potential role in periodontal healing. Dental Update. 2002 Apr 2;29(3):144-8. 19. Newman MG, Takei H, Klokkevold PR, Carranza FA. Carranza's clinical periodontology. Elsevier health sciences; 2011 Feb 14. 20. Pilloni A, Annibali S, Dominici F, Di Paolo C, Papa M, Cassini MA, Polimeni A. Evaluation of the efficacy of an hyaluronic acid-based biogel on periodontal clinical parameters. A randomized-controlled clinical pilot study. Annali di stomatologia. 2011 Mar;2(3-4):3. 21. Polepalle T, Srinivas M, Swamy N, Aluru S, Chakrapani S, Chowdary BA. Local delivery of hyaluronan 0.8% as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A clinical and microbiological study. Journal of Indian Society of Periodontology. 2015 Jan;19(1):37. 22. Puri K, Khatri M, Bansal M, Kumar A, Rehan M, Gupta A. A novel injectable platelet-rich fibrin reinforced papilla reconstruction technique. Journal of Indian Society of Periodontology. 2022 Jul;26(4):412. 23. Rajan P, Baramappa R, Rao NM, Pavaluri AK, Indeevar P, Rahaman SM. Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trail. Journal of clinical and diagnostic research: JCDR. 2014 Dec;8(12):ZC11. 24. Rakhewar PS, Jannawar Purva, Chacko Neelathi et al. An evaluation of clinical effects of injectable platelet rich fibrin as an adjunctive to non surgical periodontal therapy verses non surgical periodontal therapy alone in treatment of chronic periodontitis patient – a split mount randomized controlled trial. IOSR. Journal of dental and medical sciences volume 20, issue 9, series 5(Sept.2021). 25. Saini R, Marawar PP, Shete S, Saini S. Periodontitis, a true infection. Journal of global infectious diseases. 2009 Jul;1(2):149. 26. Shah SA, Vijayakar HN, Rodrigues SV, Mehta CJ, Mitra DK, Shah RA. To compare the effect of the local delivery of hyaluronan as an adjunct to scaling and root planing versus scaling and root planing alone in the treatment of chronic periodontitis. Journal of Indian Society of Periodontology. 2016 Sep;20(5):549. 27. Slots J. Primer for antimicrobial periodontal therapy. Journal of Periodontal research. 2000 Apr;35(2):108-14. 28. Vedamurthy M. Soft tissue augmentation-Use of hyaluronic acid as dermal filler. Indian Journal of Dermatology, Venereology and Leprology. 2004 Nov 1;70:383. 29. Vučković M, Nikolić N, Milašin J, Đorđević V, Milinković I, Asotić J, Jezdić Z, Janković S, Aleksić Z. The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. Srpski arhiv za celokupno lekarstvo. 2020;148(5-6):280-5. 30. Xu Y, Höfling K, Fimmers R, Frentzen M, Jervøe‐Storm PM. Clinical and microbiological effects of topical subgingival application of hyaluronic acid gel adjunctive to scaling and root planing in the treatment of chronic periodontitis. Journal of periodontology. 2004 Aug;75(8):1114-8.