Published October 30, 2025
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Hormones and Its Effect on Orthodontic Tooth Movement
- 1. International Journal of Dental Science and Innovative Research (IJDSIR)
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Abstract
Orthodontic treatment relies on the application of controlled forces to teeth, which initiates a cascade of mechanical, biochemical, and cellular events within the periodontal ligament (PDL) and alveolar bone. These events lead to bone remodeling, a dynamic process coordinated by osteoblasts, osteoclasts, and osteocytes. Hormones act as critical regulators of these activities, influencing the rate, quality, and stability of orthodontic tooth movement (OTM). Some hormones accelerate bone resorption and tooth movement, while others inhibit these processes. This review synthesizes available evidence on the role of key endocrine and paracrine hormones—including sex hormones, prostaglandins, thyroid hormones, parathyroid hormone, calcitonin, vitamin D, and relaxin in orthodontic tooth movement.
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