Machine Learning Discoveries of STEAP3-X Synergy in etc-1922159 Treated Colorectal Cancer Cells

Six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a metalloreductase that is capable of converting iron from an insoluble ferric (Fe3+) to a soluble ferrous (Fe2+) form. It has been found to be overexpressed in colorectal cancer. In colorectal cancer cells treated with ETC-1922159, it was found to be down-regulated. A recently developed search engine ranked combinations of STEAP3-X (X, a particular gene/protein) at 2nd order level after drug administration. In this research work, I cover combinations of STEAP3 with cyclin dependent kinase inhibitor (CDKN), glutathione peroxidase (GPX), solute carrier family (SLC), methyltransferase N6 adenosine methyltransferase complex catalytic subunit (METTL), b-cell leukemia / lymphoma protein (BCL), interleukin (IL) and transferrin receptor protein (TFR) family.