Machine Learning Discoveries of ATG3-X Synergy in ETC-1922159 Treated Colorectal Cancer Cells

Autophagy related 3 (ATG3) is one of the genes that plays a major role in autophagy. It has been found to be highly expressed in colon caner. In colorectal cancer (CRC) cells treated with ETC-1922159, ATG3 was found to be down regulated along with other genes. A recently developed search engine ranked combinations of ATG3-X (X, a particular gene/protein) at 2nd order level after drug administration. Some of these combinations have been tested in wet lab, however, there are other that have yet to be explored or tested. These rankings reveal which ATG3-X combinations might be working synergistically in CRC. In this research work, I cover combinations of ATG3 with programmed cell death (PDCD), bromodomain containing (BRD), aspartyl-tRNA synthetase (DARS), methyltransferase N6-adenosine methyltransferase non-catalytic subunit (METTL), eukaryotic translation initiation factor (EIF), forkhead box (FOX), growth arrest specific (GAS), RAB member RAS oncogene GTPases (RAB), FA complementation groups (RAD51), tripartite motif containing (TRIM) and TNF alpha induced protein (TNFAIP) family.