Machine Learning Discoveries of WNT10B-X Synergy in ETC-1922159 Treated Colorectal Cancer Cells

Wnt family member 10B (WNT10B) is a cysteine-rich glycoprotein, that is a part of the WNT signaling pathway and is implicated in a range of cancers. In colorectal cancer (CRC) cells treated with ETC-1922159, WNT10B was found to be down regulated along with other genes. A recently developed search engine ranked combinations of WNT10B-X (X, a particular gene/protein) at 2nd order level after drug administration. Some of these combinations have been tested in wet lab, however many have been pointed out by the search engine that are yet to be explored/tested. These rankings reveal which WNT10B-X combinations might be working synergistically in CRC. In this research work, I cover combinations of WNT10B with mitogen-activated protein kinase (MAPK), GATA zinc finger containing domain antisense RNA (GATA-AS), fatty acid binding protein (FABP), helicase like transcription factor (HLTF), long intergenic non-protein coding RNA (LINC-xxxxx), frizzled class receptor (FZD), homeobox (HOX), cytochrome c oxidase assembly factor (COX), fibroblast growth factor (FGF), interleukin (IL), Rac GTPase (RAC), transforming growth factor beta (TGFB), low density lipoprotein receptor-related protein (LRP), notch receptor (NOTCH), SET and MYND domain containing (SMYD) and forkhead box (FOX) family.