Machine Learning Discoveries of ATP6V(0/1)E2-X Synergy in ETC-1922159 Treated Colorectal Cancer Cells

The ATPase H+ transporting V(0/1) subunit e2 (ATP6V(0/1)E2) is a part of the vacuolor ATPases multisubunit complex. V-ATPases and ATP6AP2 are positive regulators of Wnt signaling pathway. In colorectal cancer (CRC) cells treated with ETC-1922159, many genes were found up and down regulated, individually. A recently developed search engine ranked combinations of ATP6V(0/1)E2-X (X, a particular gene/protein) at 2nd order level after drug administration. These rankings reveal which ATP6V(0/1)E2-X combinations might be working synergistically in CRC. In this research work, I cover combinations of ATP6V(0/1)E2 with Aldehyde dehydrogenase (ALDH), and homeobox (HOX) family.