ANALYSIS OF ECHOCARDIOGRAPHIC AND LV DIASTOLIC FUNCTION PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES AND CORONARY ARTERY DISEASE DEPENDING ON TARGET HBA1c LEVELS DURING FOLLOW-UP

Objective: To assess echocardiographic (EchoCG) and left ventricular diastolic function (LVDF) parameters in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) depending on target glycated hemoglobin levels during follow-up.
Materials: A total of 130 patients with T2DM and CAD were examined, with an average age of 65.6 ± 9.7 years and disease duration of 8.8 ± 5.2 and 7.5 ± 3.6 years, respectively.
Results: Analysis showed that among patients with T2DM at very high cardiovascular risk, 56.9% (n=74) achieved the target HbA1c level ≤8%. HbA1c ≥8% remained in 43.0% (n=56), taking age into account. In patients with HbA1c ≥8%, the duration of CAD and T2DM was 1.5 and 1.2 times higher than in the group with HbA1c ≤8%. Meanwhile, the frequency of atrial fibrillation paroxysms was 4.5 times higher in the group with HbA1c ≤8%. The identified associations revealed a positive relationship between HbA1c fluctuations and the risk of macrovascular complications.