Published June 30, 2025
| Version v1
Journal article
Open
Effects of Ozonized Oil vs Chlorhexidine 1% Gel in Non-Surgical Periodontal Treatment: A Comparative Clinical Study
- 1. International Journal of Dental Science and Innovative Research (IJDSIR)
Description
Abstract
Periodontal disease is the complex of dysbiotic microbiota present in dental plaque biofilm. Disrupting and removal of the dental plaque biofilms from the tooth surface is the ultimate goal of any periodontal therapy. Recent studies have suggested that ozonated oil can improve gingival health. The methodology was designed to see the effects of Ozonized (sunflower oil) oil compared to chlorhexidine gluconate gel 1% in the treatment of periodontal disease, whether applied in the dental office or at home.
There was statistically significant difference observed between Group A and Group B for MPI, BOP, PPD and CAL respectively at different time intervals. (p<0.05)
Files
HEMANT.pdf
Files
(666.9 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:cb998aed90fddd052cfc2696856374a3
|
666.9 kB | Preview Download |
Additional details
Software
References
- 1. Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15(1):30-44. 10.1038/nri3785. 2. Ranjith A, Niranjana JM, Baiju KV. Adjunctive benefit of ozonized water irrigation with mechanical debridement in the management of Stage III periodontitis: A randomized controlled clinical and biochemical study. Int J Dent Hygiene. 2021; 00:1–7. 3. Arweiler NB, Boehnke N, Sculean A, Hellwig E, Auschill TM. Differences in efficacy of two commercial 0.2% chlorhexidine mouthrinse solutions: A 4 day plaque re growth study. J Clin Periodontol 2006; 33:334 9. 4. Cline NV, Layman DL. The effects of chlorhexidine on the attachment and growth of cultured human periodontal cells. J Periodontol 1992; 63:598 602. 5. Saini R. Ozone therapy in dentistry: a strategic review. J Nat Sci Biol Med. 2011;2(2):151-153. 6. Baysan A, Whiley RA, Lynch E. Antimicrobial effect of a novel ozone- generating device on micro-organisms associated with primary root carious lesions in vitro. Caries Res. 2000;34(6):498-501. 10.1159/000016630. 7. Tartari APS, Moreira FF, Pereira MCDS, et al. Anti-inflammatory effect of ozone therapy in an experimental model of rheumatoid arthritis. Inflammation. 2020;43(3):985-993. 10.1007/s10753-020- 01184-2. 8. Zeng J, Tang Z, Zhang Y, et al. Ozonated autohemotherapy elevates PPAR-γ expression in CD4+ T cells and serum HDL-C levels, a potential immunomodulatory mechanism for treatment of psoriasis. Am J Transl Res. 2021;13(1):349-359. 9. Sanz M, Herrera D, Kebschull M, et al; On behalf of the EFP Workshop Participants and Methodological Consultants. Treatment of stage I–III periodontitis—The EFP S3 level clinical practice guideline. J Clin Periodontol. 2020; 47:4–60. https:// doi.org/ 10. 1111/jcpe.13290 10. Scribante, A., Gallo, S., Pascadopoli, M., Frani, M., & Butera, A. (2023). Ozonized gels vs chlorhexidine in non-surgical periodontal treatment: A randomized clinical trial. Oral Diseases, 00, 1–8. https:// doi.org/10.1111/odi.14829 11. Colombo, M.; Gallo, S.; Garofoli, A.; Poggio, C.; Arciola, C.R.; Scribante, A. Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application. Biology 2021, 10, 625. https://doi.org/ 10.3390/biology10070625 12. Kist, Stefan & Kollmuss, Maximilian & Jung, Jette & Schubert, Sören & Hickel, Reinhard & Huth, Karin. (2017). Comparison of ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection protocols in treating apical periodontitis: a randomized controlled clinical trial. Clinical oral investigations. 21. 10.1007/s00784-016-1849-5. 13. Checchi, Luigi & Montevecchi, Marco & Checchi, Vittorio & Zappulla, Franco. (2009). The Relationship Between Bleeding on Probing and Subgingival Deposits. An Endoscopical Evaluation. The open dentistry journal. 3. 154-60. 10.2174 /1874210600903010154. 14. Nambiar S, Malothu S, Karmakar S, Varkey A, Chandra D, Chava VK. Comparison of ozonated olive oil and chlorhexidine gel as an adjunct to nonsurgical periodontal therapy for the treatment of chronic periodontitis: A randomized controlled clinical trial. J Pharm Bioall Sci 2022;14:S94-8.