Published December 10, 2025
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What is the difference in the mechanism of action between trimethoprim and co-trimoxazole?
Description
Trimethoprim inhibits dihydrofolate reductase alone, whereas co-trimoxazole combines trimethoprim with sulfamethoxazole to inhibit both dihydrofolate reductase and dihydropteroate synthetase, enhancing antibacterial activity.