Published December 9, 2025
| Version v1
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Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy
Authors/Creators
-
Thairi, Cecilia
(Researcher)1
-
Artioli, Rebecca
(Researcher)2, 3
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PAULIS, Marianna
(Researcher)1, 4
-
Galli, Camilla
(Researcher)1, 5
- Cotič, Simon (Researcher)6, 3
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Paldino, Alessia
(Researcher)7
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Marino, Ilenia
(Researcher)8
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SINAGRA, GIANFRANCO
(Researcher)9, 8
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COLLESI, CHIARA
(Researcher)10, 3
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Dal Ferro, Matteo
(Researcher)8
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Di Pasquale, Elisa
(Researcher)1, 5
-
1.
IRCCS Humanitas Research Hospital
- 2. University of Trieste, Departiment of Life Sciences
-
3.
International Centre for Genetic Engineering and Biotechnology
-
4.
Institute of Genetic and Biomedical Research
- 5. Institute for Genetic and Biomedical Research, UOS of Milan
- 6. University of Trieste, Department of Life Sciences
-
7.
Azienda-Unita' Sanitaria Locale Di Cesena
-
8.
Azienda Sanitaria Universitaria Integrata di Trieste
- 9. University of Trieste, Department of Medical, Surgical and Health Sciences
- 10. University of Trieste, Department of LIfe Sciences
Description
This record contains raw data related to article “Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy"
Abstract
Inherited dilated cardiomyopathy (iDCM) is a disease of the heart muscle, characterized by left ventricle enlargement, systolic dysfunction and arrhythmias. iDCM represents a common cause of heart failure and the most frequent cause of heart transplantation. Among the causative genes, TTN, encoding the sarcomeric protein Titin, represents the most prevalent (about 25 % of cases). The heterogeneous clinical manifestations and variable response to therapy represent a major challenge in patients’ clinical management. To deepen the knowledge of this disease, we generated and fully characterized induced Pluripotent Stem Cell lines from 4 iDCM patients carrying 4 different truncating variants of TTN gene.
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Additional details
Related works
- Is supplemented by
- Publication: 40286602 (PMID)