THE CONTRIBUTION OF EPIGENETIC REPROGRAMMING IN THE DEVELOPMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Amyotrophic Lateral Sclerosis (ALS) is a progressive 
neurodegenerative disease that affects motor neurons, leading to muscle weakness, 
paralysis, and eventually respiratory failure. It can be classified as familial (FALS) 
or sporadic (SALS), which, although sharing pathophysiological mechanisms and 
similar clinical manifestations, differ in genetic profiles, age of onset, and 
diagnostic implications. The reprogramming of epigenetic mechanisms is also 
associated with the development of ALS; and because these alterations are 
reversible, they represent promising therapeutic targets currently under 
investigation.